To evaluate the influence of  rs10493112 variant as a genetic marker for response to second-generation androgen receptor axis-target agents. A hospital-based cohort study of 78 patients with metastatic castration-resistant prostate cancer was conducted. Genotyping was performed by TaqMan allelic discrimination technology. In abiraterone-treated and high-risk patients, rs10493112 AA genotype carriers showed lower progression-free survival than C allele genotype patients (4 vs 17 months; p = 0.009). For carriers of AA genotype, multivariate Cox regression analysis revealed a fivefold increased risk of progression (p = 0.035). The study findings suggest that, for metastatic and castration-resistant prostate cancer patients, this polymorphism might be a putative marker for the clinical outcome.

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http://dx.doi.org/10.2217/pgs-2020-0008DOI Listing

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