AI Article Synopsis
- Glioblastoma is a highly aggressive brain cancer with current treatments like surgery, chemotherapy, and radiation showing limited effectiveness.
- A study investigated the anti-tumor effects of a water extract from a medicinal mushroom called "Lingzhi," revealing it inhibits brain tumor cell proliferation and induces apoptosis and cell cycle arrest.
- The extract also significantly reduced cell migration and expression of mesenchymal markers, indicating its potential as a therapeutic option for glioblastoma treatment.
Article Abstract
Glioblastoma is one of the most common and most aggressive brain cancers. The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. (), also called "Lingzhi", is a medicinal mushroom that has been used as a therapeutic agent for the treatment of numerous diseases, including cancer. However, whether it is effective for treating cancer is still unclear. In the present study, the anti-tumor effect of a water extract of was investigated using brain tumor cells. We used an analysis of cell viability, flow cytometry, the IncuCyte live-cell analysis system, and Western blotting to study its effects. The water extract from inhibited cell proliferation in a dose- and time-dependent manner, and it induced mitochondria-mediated apoptosis and cell cycle arrest at S phase via the cyclin-CDK2 pathway in human brain tumor cells. In addition, the extract significantly inhibited cell migration and mesenchymal marker expression based on the IncuCyte live-cell assay and qRT-PCR analysis. In summary, these anti-tumor effects in brain tumor cells suggest that may be useful for treating brain tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464863 | PMC |
| http://dx.doi.org/10.3390/molecules25163585 | DOI Listing |
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