The study of aggressive driving is an important step in the reduction of (often fatal) crashes due to this behavior. However, even though various measures of aggressive driver behavior have been proposed, a more thorough examination of what the driving public perceives as aggressive driving behavior can be performed. A nationally representative sample of 198 American adults saw and rated the aggressiveness of various driving behaviors in videos. The videos were shown from a first-, second-, or third-person perspective. Some videos depicted close following, varying in speed and distance from the car ahead. Participants also saw illegal passing videos and collision or near collision videos. A number of variables that might influence judgments of aggressive driving were included as controls (i.e., trait anger, aggressive and prosocial driving attitudes, driving experience). Following other drivers closely was rated as aggressive, especially when viewed from a third-person perspective. Illegal passes were viewed as more aggressive than speeding. Faster speeds didn't increase aggressive ratings much, regardless of perspective. Aggressiveness ratings were especially high for acts that could be considered "road rage" (i.e., hitting or nearly hitting vehicles, cyclists, and pedestrians). People high in trait anger have a bias to view many driving behaviors as intentionally aggressive.
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http://dx.doi.org/10.1016/j.aap.2020.105709 | DOI Listing |
J Transl Med
January 2025
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Background: Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cancer acceleration, known as hyperprogressive disease (HPD), whose causative mechanisms are still unclear.
Methods: This study investigated the mechanisms of ICI resistance in an HPD-NSCLC model.
Commun Biol
December 2024
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Sci Rep
December 2024
Department of Medical and Surgical Sciences, Institute of Cardiology, University of Bologna, Policlinico S.Orsola-Malpighi, via Massarenti 9, Bologna, 40138, Italy.
Cardiac implantable electronic devices infections (CIEDI) are associated with poor survival despite the improvement in transvenous lead extraction (TLE). Aetiology and systemic involvement are driving factors of clinical outcomes. The aim of this study was to explore their contribute on overall mortality.
View Article and Find Full Text PDFCancer Lett
December 2024
Department of Medical Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 310003. Electronic address:
Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, lacking effective targeted therapies and presenting with a poor prognosis. In this study, we utilized the epigenomic landscape, TCGA database, and clinical samples to uncover the pivotal role of HJURP in TNBC. Our investigation revealed a strong correlation between elevated HJURP expression and unfavorable prognosis, metastatic progression, and late-stage of breast cancer.
View Article and Find Full Text PDFMicrosc Res Tech
December 2024
Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia.
This study delves into the intriguing world of extrachromosomal DNA (ecDNA) in breast cancer, uncovering its pivotal role in cancer's aggressiveness and genetic variability. ecDNA, a form of circular DNA found outside chromosomes, is known to play a significant role in cancer progression by increasing oncogene expression. Focusing on two contrasting cell lines, MDA-MB-231 (triple-negative) and MCF-7 (Luminal-A), we utilized advanced microscopy and fluorescence techniques to detect and characterize ecDNA.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!