Objectives: The objective of this study was to assess the agreement of treatment effect estimates from meta-analyses based on abbreviated or comprehensive literature searches.
Study Design And Setting: This was a meta-epidemiological study. We abbreviated 47 comprehensive Cochrane review searches and searched MEDLINE/Embase/CENTRAL alone, in combination, with/without checking references (658 new searches). We compared one meta-analysis from each review with recalculated ones based on abbreviated searches.
Results: The 47 original meta-analyses included 444 trials (median 6 per review [interquartile range (IQR) 3-11]) with 360045 participants (median 1,371 per review [IQR 685-8,041]). Depending on the search approach, abbreviated searches led to identical effect estimates in 34-79% of meta-analyses, to different effect estimates with the same direction and level of statistical significance in 15-51%, and to opposite effects (or effects could not be estimated anymore) in 6-13%. The deviation of effect sizes was zero in 50% of the meta-analyses and in 75% not larger than 1.07-fold. Effect estimates of abbreviated searches were not consistently smaller or larger (median ratio of odds ratio 1 [IQR 1-1.01]) but more imprecise (1.02-1.06-fold larger standard errors).
Conclusion: Abbreviated literature searches often led to identical or very similar effect estimates as comprehensive searches with slightly increased confidence intervals. Relevant deviations may occur.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jclinepi.2020.08.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early Strength Enhancement Mechanism of CaO-Modified Electrolytic Manganese Residue-Based Supersulfate Cement.
Materials (Basel)
January 2025
Guizhou Provincial Architectural Design & Research Institute Co., Ltd., Guiyang 550025, China.
Electrolytic manganese residue (EMR) is a solid waste generated during the production of electrolytic manganese metal through wet metallurgy, accumulating in large quantities and causing significant environment pollution. Due to its high sulfate content, EMR can be utilized to prepare supersulfate cement when combined with Ground Granulated Blast furnace Slag (GGBS). In this process, GGBS serves as the primary raw material, EMR acts as the sulfate activator, and CaO powder, along with trace amounts of cement, functions as the alkali activator.
View Article and Find Full Text PDFComposites of YF: Yb, Er, Tm@CN-Au with near-infrared light-driven ability for photocatalytic wastewater purification.
RSC Adv
January 2025
College of Environment and Chemical Engineering, Dalian University Dalian 116622 Liaoning P. R. China
Photocatalytic technology for removing organic dye pollutants has gained considerable attention because of its ability to harness abundant solar energy without requiring additional chemical reagents. In this context, YF spheres doped with Yb, Er, Tm (YF) are synthesized using a hydrothermal method and are subsequently coated with a layer of graphitic carbon nitride (g-CN) with Au nanoparticles (NPs) adsorbed onto the surface to create a core-shell structure, designated as YF: Yb, Er, Tm@CN-Au (abbreviated as YF@CN-Au). The core-shell composites demonstrate remarkable stability, broadband absorption, and exceptional photocatalytic activity across the ultraviolet (UV) to near-infrared (NIR) spectral range.
View Article and Find Full Text PDFPurpose: Cancer-related financial toxicity occurs frequently and is a key driver of inequities in access to care and disparities in treatment outcomes. Current practices to screen for financial toxicity are inconsistent because of the lack of a validated and clinically integrated screening tool. This analysis aimed to create and assess an abbreviated version of the validated Comprehensive Score for Financial Toxicity (COST) tool, a measure of financial toxicity used for research purposes, which could easily be added into often-lengthy clinical screening workflows.
View Article and Find Full Text PDFEffect analysis of unilateral deaf adults wearing bone-conduction hearing aids: A case report.
J Otol
October 2024
Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.
The prevalence of unilateral deafness (SSD) or asymmetric hearing loss (AHL) among patients with hearing impairments ranges from 7.2% to 15.0%, indicating a relatively significant proportion.
View Article and Find Full Text PDFThe performance of abbreviated comprehensive geriatric assessment in elderly patients with diffuse large B cell lymphoma.
Support Care Cancer
January 2025
Department of Hematology and Oncology, Geriatric Medical Center, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, 5 Fu-Hsing Street, Kwei-Shan Shiang, Taoyuan, Taiwan.
Purpose: Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive forms of non-Hodgkin's lymphoma. This study aimed to evaluate the performance of the abbreviated Comprehensive Geriatric Assessment (aCGA) in assessing frailty and predicting clinical outcomes in elderly patients with DLBCL.
Methods: A total of 91 patients aged ≥ 65 years with newly diagnosed DLBCL and who received immunochemotherapy at a single medical center in Taiwan between August 2019 and December 2022 were prospectively enrolled.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!