AI Article Synopsis
- Researchers are exploring new prognostic markers to better predict clinical outcomes for chronic lymphocytic leukemia (CLL) patients, despite existing markers.
- The study analyzed serum samples from 51 CLL patients before treatment, identifying key proteomic markers linked to treatment response.
- High levels of markers like sCD23, sCD27, SPINT1, and LY9 were associated with shorter event-free survival, especially among patients with unmutated immunoglobulin heavy chain variable genes.
Article Abstract
Despite recent identification of several prognostic markers, there is still a need for new prognostic parameters able to predict clinical outcome in chronic lymphocytic leukemia (CLL) patients. Here, we aimed to validate the prognostic ability of known (proteomic) markers measured pretreatment and to search for new proteomic markers that might be related to treatment response in CLL. To this end, baseline serum samples of 51 CLL patients treated with chemo-immunotherapy were analyzed for 360 proteomic markers, using Olink technology. Median event-free survival (EFS) was 23 months (range: 1.25-60.9). Patients with high levels of sCD23 (>11.27, p = 0.026), sCD27 (>11.03, p = 0.04), SPINT1 (>1.6, p = 0.001), and LY9 (>8.22, p = 0.0003) had a shorter EFS than those with marker levels below the median. The effect of sCD23 on EFS differed between immunoglobulin heavy chain variable gene-mutated and unmutated patients, with the shortest EFS for unmutated CLL patients with sCD23 levels above the median. Taken together, our results validate the prognostic impact of sCD23 and highlight SPINT1 and LY9 as possible promising markers for treatment response in CLL patients.
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| http://dx.doi.org/10.1016/j.exphem.2020.08.002 | DOI Listing |
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