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Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology.
Virchows Arch
November 2024
Laboratory of Clinical and Experimental Pathology, Hospital-Related Biobank BB0033-00025, Nice University Hospital, University Côte d'Azur, FHU OncoAge, IHU RespirERA, 06000, Nice, France.
Despite advancements in precision medicine, many cancer patients globally, particularly those in resource-constrained environments, face significant challenges in accessing high-quality molecular testing and targeted therapies. The considerable heterogeneity in molecular testing highlights the urgent need to harmonize practices across Europe and beyond, establishing a more standardized and consistent approach in MP laboratories. Professionals, especially molecular pathologists, must move beyond traditional education to cope with this heterogeneity.
View Article and Find Full Text PDFA critical spotlight on the paradigms of FFPE-DNA sequencing.
Nucleic Acids Res
August 2023
Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Medical Center Schleswig-Holstein, Kiel 24105, Germany.
In the late 19th century, formalin fixation with paraffin-embedding (FFPE) of tissues was developed as a fixation and conservation method and is still used to this day in routine clinical and pathological practice. The implementation of state-of-the-art nucleic acid sequencing technologies has sparked much interest for using historical FFPE samples stored in biobanks as they hold promise in extracting new information from these valuable samples. However, formalin fixation chemically modifies DNA, which potentially leads to incorrect sequences or misinterpretations in downstream processing and data analysis.
View Article and Find Full Text PDFHome alone: A population neuroscience investigation of brain morphology substrates.
Neuroimage
April 2023
The Neuro, Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre (BIC), McGill University, Montreal, QC, Canada; Department of Biomedical Engineering, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada; Mila - Quebec Artificial Intelligence Institute, Montreal, QC, Canada.
As a social species, ready exchange with peers is a pivotal asset - our "social capital". Yet, single-person households have come to pervade metropolitan cities worldwide, with unknown consequences in the long run. Here, we systematically explore the morphological manifestations associated with singular living in ∼40,000 UK Biobank participants.
View Article and Find Full Text PDFSession Introduction: Precision Medicine: Using Artificial Intelligence to Improve Diagnostics and Healthcare.
Pac Symp Biocomput
December 2022
Department of Biomedical Data Science, Stanford School of Medicine, Stanford, CA, United States,
Precision medicine requires a deep understanding of complex biomedical and healthcare data, which is being generated at exponential rates and increasingly made available through public biobanks, electronic medical record systems and biomedical databases and knowledgebases. The complexity and sheer amount of data prohibit manual manipulation. Instead, the field depends on artificial intelligence approaches to parse, annotate, evaluate and interpret the data to enable applications to patient healthcare At the 2023 Pacific Symposium on Biocomputing (PSB) session entitled "Precision Medicine: Using Artificial Intelligence (AI) to improve diagnostics and healthcare", we spotlight research that develops and applies computational methodologies to solve biomedical problems.
View Article and Find Full Text PDFBiobanking Spotlight on Europe, Middle East, and Africa: Presenting the Collective Experience of the ISBER-EMEA Regional Ambassadors.
Biopreserv Biobank
October 2020
Wales Cancer Bank, Cardiff University School of Medicine, College of Biomedical and Life Sciences, Cardiff, United Kingdom.
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