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Incidence of hospital-acquired infections due to carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa in critically ill patients in Italy: a multicentre prospective cohort study.
Crit Care
January 2025
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Background: Carbapenem-Resistant Gram-Negative Bacteria, including Carbapenem-Resistant Enterobacterales (CRE) and Carbapenem-Resistant Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (ICUs) in Italy.
Objective: This prospective observational study evaluated the epidemiology, management, microbiological characterization, and outcomes of hospital-acquired CRE or CRPA infections treated in selected ICUs in Italy.
Methods: The study included patients with hospital-acquired infections due to CRE and CRPA treated in 20 ICUs from June 2021 to February 2023.
Phenotypic and Genotypic Detection of Hypervirulent Isolated from Hospital-Acquired Infections.
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December 2024
Department of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Hypervirulent is a highly pathogenic variant of , which represents a global public health issue because it is very virulent and spreads easily. The objectives of this study were to assess the predominance of hvKp among health care-associated infections in intensive care units of Tanta University Hospital and to compare hvKp with classical (cKp) in terms of antibiotic resistance, virulence, and molecular features. The study included 300 patients suffering from HAIs from different ICUs of Tanta University Hospitals.
View Article and Find Full Text PDFSilicene-Based Quantum Dots Nanocomposite Coated Functional UV Protected Textiles With Antibacterial and Antioxidant Properties: A Versatile Solution for Healthcare and Everyday Protection.
Adv Healthc Mater
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School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada.
The predominant adverse health effects in care delivery result from hospital-acquired (nosocomial) infections, which impose a substantial financial burden on global healthcare systems. Integrating contact-killing antibacterial action, gas permeability, and antioxidant properties into textile coatings offers a transformative solution, significantly enhancing both medical and everyday protective applications. This study presents an innovative, pollution-free physical compounding method for creating a fluorescent biopolymer composite embedded with silicene-based heteroatom-doped carbon quantum dots for the production of functional textiles.
View Article and Find Full Text PDFMolecular Characteristics of Community-Acquired Methicillin-Resistant , Hospital-Acquired MRSA Isolates, and PVL in one of the Indian hospitals.
Indian J Microbiol
December 2024
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 India.
Unlabelled: Community-acquired methicillin resistant (CA-MRSA) strains are increasingly replacing hospital-acquired MRSA (HA-MRSA) strains in hospitalized patients leading to poor clinical outcomes. Hence, this study aimed to characterize clinical isolates of MRSA (HA-MRSA and CA-MRSA) and to understand their clonal origin. A total of 400 consecutive clinical isolates were collected from the clinical bacteriology lab of a tertiary care hospital.
View Article and Find Full Text PDFNew multilocus sequence typing scheme for reveals sequential outbreaks of vancomycin-resistant ST1162 and ST610 in a Japanese tertiary medical center.
Microbiol Spectr
January 2025
Department of Clinical Laboratory and Biomedical Sciences, Laboratory of Medical Microbiology and Microbiome, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Article Synopsis
- Vancomycin-resistant Enterococcus faecium (VREfm) is a significant hospital pathogen, and effective control relies on advanced molecular epidemiological tools.
- Pulsed-field gel electrophoresis (PFGE) is still widely used in clinical labs, but with the decline in PFGE equipment availability, the Bezdíček multilocus sequence typing (MLST) scheme has been proposed as a more accurate alternative for analyzing genetic similarities among VREfm strains.
- Comparing both MLST schemes with PFGE, the study found that the Bezdíček scheme offers improved outbreak visualization and higher discriminatory power, making it a valuable tool for managing VREfm infections in healthcare settings.
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