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| http://dx.doi.org/10.1002/pbc.28432 | DOI Listing |
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Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease.
Infect Drug Resist
December 2024
Department of Cardiovascular Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Background: The emergence of the Omicron variant of severe acute respiratory syndrome coronavirus-2 has significantly altered the clinical features and severity of coronavirus disease 2019 (COVID-19).
Objective: This study aims to evaluate whether the clinical factors that previously predicted COVID-19 remain valid following the emergence of the Omicron variant.
Methods: This cross-sectional study was conducted at Showa University Fujigaoka Hospital from April 2022 to March 2023.
Structural proteins of human coronaviruses: what makes them different?
Front Cell Infect Microbiol
December 2024
Biology Department, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Following COVID-19 outbreak with its unprecedented effect on the entire world, the interest to the coronaviruses increased. The causative agent of the COVID-19, severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) is one of seven coronaviruses that is pathogenic to humans. Others include SARS-CoV, MERS-CoV, HCoV-HKU1, HCoV-OC43, HCoV-NL63 and HCoV-229E.
View Article and Find Full Text PDFTechnology use in long-term care during the COVID-19 pandemic: A qualitative study of paid employees' experiences in Western Canada.
Digit Health
December 2024
School of Nursing, University of Northern British Columbia, Prince George, BC, Canada.
Background: During the COVID-19 pandemic, governments across the world implemented processes and policies to limit the spread of COVID-19, especially in long-term care (LTC) homes. This led to changes in technology use for persons living in LTC homes, their families and friends, as well as the paid workforce dedicated to caring for them.
Objective: The study describes the role of technology and its impact on the experiences of LTC staff working in northern and rural areas in Western Canada during COVID-19.
A breath of fresh air: inhaled antibodies to combat respiratory infectious diseases - a clinical trial overview.
Expert Opin Drug Deliv
December 2024
Université de Tours, Centre d'Etude des Pathologies Respiratoires, Tours, France.
Introduction: With the worldwide growing burden of respiratory tract infections (RTIs), innovative therapeutic approaches are in high demand. Inhaled antibodies (Abs) represent a promising avenue, offering targeted treatment options with potentially better therapeutic index compared to traditional delivery methods.
Areas Covered: This comprehensive review summarizes the challenges faced in delivering Abs by (intranasal and pulmonary) inhalation.
Influence of HLA-G 3' Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort.
HLA
December 2024
Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
HLA-G, an important immune-checkpoint (IC) molecule that exerts inhibitory signalling on immune effector cells, has been suggested to represent a key player in regulating the immune response to Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2). Since specific single-nucleotide polymorphisms (SNP) in the HLA-G 3'untranslated region (UTR), which arrange as haplotypes, are crucial for the regulation of HLA-G expression, we analysed the contribution of these genetic variants as host factors in SARS-CoV-2 infection during acute and post-acute phases. HLA-G gene polymorphisms in the 3'UTR were investigated by sequencing in an unvaccinated Coronavirus Disease 2019 (COVID-19) cohort during acute SARS-CoV-2 infection (N = 505) and in the post-acute phase (N = 253).
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