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Organoids, tissue slices and organotypic cultures: advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models.
Semin Cancer Biol
December 2024
Amsterdam UMC location University of Amsterdam, Laboratory of Experimental Oncology and Radiobiology, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Biology, Amsterdam, the Netherlands. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses of all common solid cancers. For the large majority of PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought the advances seen in other cancer types.
View Article and Find Full Text PDFCase report: Brain infarction following percutaneous drainage of a liver abscess post-chemotherapy for pancreatic head cancer.
Front Med (Lausanne)
December 2024
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Bacterial liver abscesses commonly occur in patients with immune deficiencies such as diabetes, post-chemotherapy, or post-immunosuppressive therapy. The recommended treatment for liver abscesses exceeding 5 cm in a diameter is anti-infection therapy combined with percutaneous catheter drainage. Complications may include local spread to adjacent tissues or organs and thrombosis of the liver and portal veins.
View Article and Find Full Text PDFMetabolite Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: A Systematic Review.
Cureus
November 2024
Internal Medicine, Mayo Hospital, Lahore, PAK.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a poor prognosis. This poor prognosis is largely attributed to a late-stage diagnosis. Recent advancements in metabolomics have emerged as a promising avenue for biomarker discovery in PDAC.
View Article and Find Full Text PDFPoint shear wave elastography application in assessment pancreas tissue stiffness: A pilot study.
Radiography (Lond)
December 2024
Radiology Department, College of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Electronic address:
Introduction: Recent advancements in medical imaging, such as point shear wave elastography (pSWE), offer non-invasive methods to assess tissue stiffness and structural changes. This study explores the use of pSWE to evaluate pancreatic stiffness and dimensions in three different pancreas parts.
Methods: This study was conducted at diagnostic radiology department, King Abdulaziz University Hospital, Jeddah, between June 2022 and November,2022.
Exploring the gut microbiome: A potential biomarker for cancer diagnosis, prognosis, and therapy.
Biochim Biophys Acta Rev Cancer
December 2024
Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea. Electronic address:
The gut microbiome, a complex community of trillions of microorganisms in the intestines, is crucial in maintaining human health. Recent advancements in microbiome research have unveiled a compelling link between the gut microbiome and cancer development and progression. Alterations in the composition and function of the gut microbiome, known as dysbiosis, have been implicated in various types of cancer, including, esophageal, liver, colon, pancreatic, and gastrointestinal.
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