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Investigating How Age Affects Self-Perception and Voice Awareness in Parkinson's Disease.
J Voice
March 2025
Department of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain.
Objective: Parkinson's disease (PD) presents with voice disturbances accompanied by sensory processing and awareness deficits. Sensory feedback from the voice, which is essential in speech production, is often impaired in individuals with PD (IwPD), potentially leading to such difficulties in the self-perception and awareness of voice disorder. However, aging naturally affects sensory and motor brain systems, including those involved in voice production; therefore, it remains unclear whether the combined effects of age and PD exacerbate deficits in voice self-perception and awareness deficit.
View Article and Find Full Text PDFAging Impacts Basic Auditory and Timing Processes.
Eur J Neurosci
March 2025
Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Deterioration in the peripheral and central auditory systems is common in older adults and often leads to hearing and speech comprehension difficulties. Even when hearing remains intact, electrophysiological data of older adults frequently exhibit altered neural responses along the auditory pathway, reflected in variability in phase alignment of neural activity to speech sound onsets. However, it remains unclear whether challenges in speech processing in aging stem from more fundamental deficits in auditory and timing processes.
View Article and Find Full Text PDFA new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse.
Neuropsychopharmacology
February 2025
Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
The drug development process in psychiatry faces significant challenges due to low reproducibility rates in animal testing, which often leads to translation failures. To address this issue, we introduce a new approach in psychiatric drug development: a preclinical randomized controlled trial (preRCT). To demonstrate its potential utility, we conducted a multi-center preRCT using the alcohol deprivation effect (ADE) model to assess the impact of ketamine and R-ketamine on alcohol relapse across three European research centers.
View Article and Find Full Text PDFSystemic barriers and stigma: Healthcare provider perspectives on perinatal and neonatal care in the fentanyl crisis.
J Subst Use Addict Treat
February 2025
Chestnut Health Systems-Lighthouse Institute, Eugene, OR, United States of America.
Introduction: The rise in fentanyl use during pregnancy has created new challenges in caring for women with opioid use disorders (OUD) and their infants with neonatal abstinence syndrome or neonatal opioid withdrawal syndrome (NAS/NOWS). Despite complexities in treating opioid-affected dyads, little research exists on healthcare workers' perspectives regarding fentanyl's impact on perinatal and neonatal care.
Objectives: Explore dynamic challenges fentanyl has brought to the care of perinatal women with OUD and their infants experiencing NAS/NOWS from healthcare providers' perspectives.
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