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Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma.
Acta Otolaryngol
December 2024
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: There is a lack of prognosticators of overall survival (OS) for Oral Squamous Cell Carcinoma (OSCC).
Objectives: We examined collaborative machine learning (cML) in estimating the OS of OSCC patients. The prognostic significance of the clinicopathological parameters was examined.
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer.
Cell Biosci
December 2024
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy.
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC).
View Article and Find Full Text PDFGlasgow Prognostic Score and Outcomes in Elderly Head and Neck Cancer Surgery With Free-Flap Reconstruction: A Retrospective Study.
Cureus
November 2024
Department of Otolaryngology, Head and Neck Surgery, Ageo Central General Hospital, Ageo, JPN.
Background Determining good candidates for head and neck cancer surgery in elderly patients requires consideration of various factors, such as overall health and social background, yet specific evaluation guidelines are lacking. The Glasgow Prognostic Score (GPS) is a marker used to assess nutritional status and prognosis in cancer patients. Objective This study aims to evaluate the association between the GPS and both the prognosis and postoperative complications in reconstructive surgery cases for head and neck cancer in patients aged 80 and over.
View Article and Find Full Text PDFImplications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination survey from 2005 - 2018.
Diabetol Metab Syndr
December 2024
Center of Coronary Heart Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Background: Diabetes mellitus (DM) is a metabolic disorder with increasing prevalence and poor control rates, leading to adverse events. Prognostic nutritional value (PNI) has been identified as a protective factor in DM, but its role in uncontrolled DM remains unclear.
Methods: This study based on the representative cohort of National Health and Nutrition Examination Survey from 2005 to 2018.
The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study.
Head Neck
December 2024
Head and Neck Unit, The Royal Marsden Hospital, London, UK.
Background: To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) and describe survival outcomes.
Methods: Post hoc subgroup analysis of a retrospective national observational cohort was conducted. All patients with rHNSCC who received a definitive treatment decision between September 1, 2021 and November 30, 2021 were included.
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