AI Article Synopsis
- Diabetes mellitus (DM) increases fracture risk due to bone and microvascular issues, and this study investigates its potential link to sarcopenia, as previous research has been inconclusive.* -
- A systematic review analyzed 15 studies with over 1,800 type 2 DM patients, finding that those with DM had a 1.55 times higher risk of developing sarcopenia compared to individuals with normal glucose levels.* -
- The findings indicated that patients with type 2 DM had significantly lower muscle performance and strength, but no difference in muscle mass when compared to euglycemic subjects, confirming the association with sarcopenia risk.*
Article Abstract
Diabetes mellitus (DM) is associated with an increased risk of fractures, mainly due to impaired bone architecture and microvascular complications. Whether DM is also associated with increased risk of sarcopenia is not yet known, with studies yielding inconclusive results. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between DM and sarcopenia risk. A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases. Data are expressed as odds ratio (OR) with 95% confidence intervals (CI). The I index was employed for heterogeneity. Only studies which had implemented at least two of the three criteria for sarcopenia diagnosis (low muscle mass, muscle strength and/or muscle performance), as defined by the international studying groups, were included. Fifteen studies fulfilled eligibility criteria, yielding a total of 1832 patients with type 2 DM (T2DM) and 1159 cases of sarcopenia. Patients with T2DM demonstrated a higher risk of sarcopenia compared with euglycemic subjects (OR 1.55, 95% CI 1.25-1.91, p < 0.001; I 34.6%). This risk remained significant when analysis was restricted to studies matched for age and sex. Sarcopenia risk was independent of disease definition or study design. Notably, T2DM patients presented lower muscle performance and strength compared with euglycemic subjects, whereas no difference in muscle mass was observed between groups. Patients with T2DM have an increased risk of sarcopenia compared with euglycemic subjects.
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| http://dx.doi.org/10.1007/s00223-020-00742-y | DOI Listing |
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