AI Article Synopsis
Article Abstract
Biodiesel is considered as a valuable and less toxic alternative to diesel. However, cellular and molecular effects of repeated exposure to biodiesel emissions from a recent engine equipped with a diesel particle filter (DPF) remain to be characterized. To gain insights about this point, the lung transcriptional signatures were analyzed for rats (n = 6 per group) exposed to filtered air, 30% rapeseed biodiesel (B30) blend or reference diesel (RF0), upstream and downstream a DPF, for 3 weeks (3 h/day, 5 days/week). Genomic analysis revealed a modest regulation of gene expression level (lower than a 2-fold) by both fuels and a higher number of genes regulated downstream the DPF than upstream, in response to either RF0 or to B30 exhaust emissions. The presence of DPF was found to notably impact the lung gene signature of rats exposed to B30. The number of genes regulated in common by both fuels was low, which is likely due to differences in concentrations of regulated pollutants in exhausts, notably for compound organic volatiles, polycyclic aromatic hydrocarbons, NO or NOx. Nevertheless, we have identified some pathways that were activated for both exhaust emissions, such as integrin-, IGF-1- and Rac-signaling pathways, likely reflecting the effects of gas phase products. By contrast, some canonical pathways relative to "oxidative phosphorylation" and "mitochondrial dysfunction" appear as specific to B30 exhaust emission; the repression of transcripts of mitochondrial respiratory chain in lung of rats exposed to B30 downstream of DPF supports the perturbation of mitochondria function. This study done with a recent diesel engine (compliant with the European IV emission standard) and commercially-available fuels reveals that the diesel blend composition and the presence of an after treatment system may modify lung gene signature of rats repeatedly exposed to exhaust emissions, however in a rather modest manner.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.envpol.2020.115264 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimal control of Hydrocarbon Reducer (HC) injection based on Trust-Region-Reflective Algorithm (TRRA) and physical models for Diesel Oxidation Catalyst (DOC).
J Hazard Mater
December 2024
State Key Laboratory of Automotive Simulation and Control, Jilin University, Changchun 130025, China; College of Automotive Engineering, Jilin University, Changchun 130025, China.
The aim of this paper is to control the DOC outlet gas temperature between 600 ± 15 °C by optimizing the hydrocarbon (HC) injection into the Diesel Oxidation Catalyst (DOC) for active regeneration of the downstream Diesel Particulate Filter (DPF). First, based on the physical model of the DOC thermal dynamics, the energy conservation equation for the gas phase temperature is simplified by using variable substitution, and the energy conservation equation for the solid phase temperature is simplified by considering only the heat generated by the HC injection. By solving the simplified model using the Trapezoidal Rule-Backward Differentiation Formula 2 (TR-BDF2) method and optimizing the model parameters in combination with the Gauss-Newton method, the computational efficiency and accuracy were significantly improved.
View Article and Find Full Text PDFHistological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis.
Biol Sex Differ
September 2024
Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, No. 1 Xingyu Road, Xilang, Liwan District, Guangzhou, 510380, Guangdong, China.
Background: Blotched snakehead (Channa maculata) displays significant sexual dimorphism, with males exhibiting faster growth rates and larger body sizes compared to females. The cultivation of the all-male population of snakeheads holds substantial economic and ecological value. Nonetheless, the intricate processes governing the development of bipotential gonads into either testis or ovary in C.
View Article and Find Full Text PDFAHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos.
Environ Pollut
March 2024
Suzhou Medical College of Soochow University, Suzhou, China; MOE Education Key Laboratory of Geriatric Diseases and Immunology, Suzhou, China. Electronic address:
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ) has raised significant concerns due to its widespread distribution and high toxicity to aquatic organisms. However, the cardiac developmental toxicity of 6PPDQ and the underlying mechanisms remain unclear. In this study, we observed no notable alterations in heart morphology or embryo survival in zebrafish embryos exposed to 6PPDQ (0.
View Article and Find Full Text PDFMicroinjection of β-glucan Into Larval Zebrafish () for the Assessment of a Trained-Like Immunity Phenotype.
Bio Protoc
December 2023
Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
The innate immune system can previous inflammatory insults, enabling long-term heightened responsiveness to secondary immune challenges in a process termed "trained immunity." Trained innate immune cells undergo metabolic and epigenetic remodelling and, upon a secondary challenge, provide enhanced protection with therapeutic potential. Trained immunity has largely been studied in innate immune cells in vitro or following ex vivo re-stimulation where the primary insult is typically injected into a mouse, adult zebrafish, or human.
View Article and Find Full Text PDFEthyl Acetate Fraction of Induces Apoptosis via JNK/Nur77 Pathway in Hepatocellular Carcinoma Cells.
Evid Based Complement Alternat Med
August 2022
Traditional Chinese Pharmacological Laboratory, Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Background: Hepatocellular carcinoma (HCC) is characterized by poor diagnosis and high mortality. Novel and efficient therapeutic agents are urgently needed for the treatment. (HDW) is used to treat cancers, especially HCC in China.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!