Background: The LUCAS (Lund University Cardiopulmonary Assist System; Physio-Control Inc./Jolife AB, Lund, Sweden) was developed for automatic chest compressions during cardiopulmonary resuscitation (CPR). Evidence on the use of this device in out-of-hospital cardiac arrest (OHCA) suggests that it should not be used routinely because it has no superior effects.
Objective: The aim of this study was to compare the effect of CPR for OHCA with and without LUCAS via a regional nonurban emergency medical service (EMS) physician-present prehospital medical system.
Methods: We analyzed a prospective registry of all consecutive OHCA patients in four EMS stations. Two of them used a LUCAS device in all CPR, and the EMS crews in the other two stations used manual CPR. Individuals with contraindication to LUCAS or with EMS-witnessed arrest were excluded.
Results: Data from 278 patients were included in the analysis, 144 with LUCAS and 134 with manual CPR. There were more witnessed arrests in the LUCAS group (79.17% vs. 64.18%; p = 0.0074) and patients in the LUCAS group were older (p = 0.03). We found no significant difference in return of spontaneous circulation (30.6% in non-LUCAS vs. 25% in LUCAS; p = 0.35). In the LUCAS group, we observed significantly more conversions from nonshockable to shockable rhythm (20.7% vs. 10.10%; p = 0.04). The 30-day survival rate was significantly lower in the LUCAS group (5.07% vs. 16.31% in the non-LUCAS group; p = 0.044). At 180-day follow-up, we observed no significant difference (5.45% in non-LUCAS vs. 9.42% in LUCAS; p = 0.25).
Conclusions: Use of the LUCAS system decreased survival rate in OHCA patients. Significantly higher 30-day mortality was seen in LUCAS-treated patients.
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http://dx.doi.org/10.1016/j.jemermed.2020.06.022 | DOI Listing |
Clin Transl Immunology
January 2025
Infectious Diseases Group, Infection, Immunity and Global Health Theme Murdoch Children's Research Institute Parkville VIC Australia.
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to vaccines against SARS-CoV-2.
Methods: Blood samples, from a subset of 275 SARS-CoV-2-naïve healthcare workers randomised to BCG vaccination (BCG group) or no BCG vaccination (Control group) in the BRACE trial, were collected before and 28 days after the primary course (two doses) of ChAdOx1-S (Oxford-AstraZeneca) or BNT162b2 (Pfizer-BioNTech) vaccination.
Pediatr Blood Cancer
January 2025
Lifespan Cancer Institute and Legorreta Cancer Center at Brown University, Providence, Rhode Island, USA.
Purpose: To explore the potential relationship between social media (SoMe) and burnout or overall wellbeing within the field of oncology.
Design: A cross-sectional study of adult and pediatric oncology professionals conducted using an anonymous electronic survey. The survey was disseminated through the Children's Oncology Group (COG) and the SWOG Cancer Research Network (SWOG) member listservs.
J Biomech
January 2025
Instituto Brasil de Tecnologias da Saúde, Rua Visconde de Piraja, 407 suite 905, Rio de Janeiro, RJ 22410-003, Brazil; Depto. de Diagnóstico por Imagem - Escola Paulista de Medicina, Universidade Federal de São Paulo, R. Napoleão de Barros, 800, São Paulo, SP, Brazil. Electronic address:
Anterior Shoulder Instability (ASI) is a common orthopedic condition often resulting in altered shoulder kinematics. Understanding the biomechanics of the unstable shoulder is critical to determine the most appropriate treatment. This study aims to conduct the first systematic review and meta-analysis of three-dimensional (3D) shoulder kinematic studies in ASI patients.
View Article and Find Full Text PDFVet Sci
December 2024
Grupo de Pesquisa em Patologia Animal no Bioma Amazônico, Centro de Diagnóstico Animal, Programa de Pós-Graduação em Ciências Ambientais, Universidade Federal de Rondônia, Rolim de Moura 76940000, Brazil.
This study investigated the abundance of zooplankton copepods and ostracods taxonomic groups in fish farms in Rondônia's Vale do Jamari and Centro-Leste microregions during the rainy and dry seasons. It also analyzed the correlation between zooplanktons abundance and the presence of acanthocephalan parasites. Conducted in 41 fish farms between November 2021 and September 2023, the study included water, zooplankton, and fish samples from 196 .
View Article and Find Full Text PDFJ Am Soc Nephrol
December 2025
Department of Medicine, Division of Nephrology, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.
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