AI Article Synopsis
- This study conducted a meta-analysis to explore the link between vitamin D receptor (VDR) gene polymorphisms and type 1 diabetes mellitus (T1DM), previously inconclusive in multiple studies.
- A systematic search identified 39 relevant studies, and results showed no overall significant association, but subgroup analyses indicated ethnic variations, with specific polymorphisms linked to T1DM risk in African and American populations.
- The findings suggest that VDR gene polymorphisms may influence T1DM susceptibility, emphasizing the need for more targeted ethnic-specific research.
Article Abstract
Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.
Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle-Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed.
Results: A total of 39 case-control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively.
Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414991 | PMC |
| http://dx.doi.org/10.1186/s12902-020-00575-8 | DOI Listing |
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