AI Article Synopsis
- * Highlights issues with current treatments, including cardiovascular risks and poor response to ESAs, prompting the search for new therapeutic options.
- * Discusses hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in clinical trials as promising alternatives that stimulate red blood cell production and manage iron metabolism.
Article Abstract
To investigate current treatment practices for anemia in patients with chronic kidney disease (CKD), issues surrounding current treatment practices, and the hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) that are currently in clinical trials. Treatment of anemia in patients with CKD has traditionally included iron supplementation and erythropoiesis-stimulating agents (ESAs). However, due to adverse cardiovascular (CV) events and hypo-responsiveness to ESA therapy, new agents are currently in clinical trials to treat anemia in patients with CKD. The HIF-PHIs stimulate erythropoiesis and regulate iron metabolism and are attractive alternatives to iron supplementation and ESAs.
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| http://dx.doi.org/10.1007/s11255-020-02584-x | DOI Listing |
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