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Spectral photon-counting CT imaging of colorectal peritoneal metastases: initial experience in rats. | LitMetric

AI Article Synopsis

  • - SPCCT is a new imaging technology that improves upon conventional CT by providing better spatial and contrast resolution, which is essential for mapping the spread of peritoneal metastases (PM) before surgery.
  • - In a study involving 16 rats with induced tumors, SPCCT demonstrated a sensitivity of 69%, specificity of 100%, and accuracy of 80% for detecting PM, showing a strong correlation with surgical findings.
  • - The research found that peritoneal metastases displayed low vascularization, indicating they have poor blood supply, which was confirmed through additional microscopic analysis, highlighting the potential of SPCCT for evaluating PM in preoperative assessments.

Article Abstract

Computed tomography imaging plays a major role in the preoperative assessment of tumor burden by providing an accurate mapping of the distribution of peritoneal metastases (PM). Spectral Photon Counting Computed Tomography (SPCCT) is an innovative imaging modality that could overcome the current limitations of conventional CT, offering not only better spatial resolution but also better contrast resolution by allowing the discrimination of multiple contrast agents. Based on this capability, we tested the feasibility of SPCCT in the detection of PM at different time of tumor growth in 16 rats inoculated with CC531 cells using dual-contrast injection protocols in two compartments (i.e. intravenous iodine and intraperitoneal gadolinium or the reverse protocol), compared to surgery. For all peritoneal regions and for both protocols, sensitivity was 69%, specificity was 100% and accuracy was 80%, and the correlation with surgical exploration was strong (p = 0.97; p = 0.0001). No significant difference was found in terms of diagnostic performance, quality of peritoneal opacification or diagnostic quality between the 2 injection protocols. We also showed poor vascularization of peritoneal metastases by measuring low concentrations of contrast agent in the largest lesions using SPCCT, which was confirmed by immunohistochemical analyses. In conclusion, SPCCT using dual-contrast agent injection protocols in 2 compartments is a promising imaging modality to assess the extent of PM in a rat model.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414131PMC
http://dx.doi.org/10.1038/s41598-020-70282-wDOI Listing

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