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Prospective Analysis of the Impact of 68Ga-DOTATOC Positron Emission Tomography-Computerized Axial Tomography on Management of Pancreatic and Small Bowel Neuroendocrine Tumors. | LitMetric

AI Article Synopsis

  • - A clinical trial assessed how Ga-DOTATOC PET-CT influences the treatment decisions for patients with neuroendocrine tumors in the lung, pancreas, and small bowel, focusing on patients with confirmed tumors expressing somatostatin receptors.
  • - Changes in management were rated as no change, minor change, or major change, with significant adjustments recommended for about 47% of the subjects based on the imaging results.
  • - Despite some mild adverse events reported, the study indicates that Ga-DOTATOC PET-CT imaging is crucial in guiding treatment plans for these patients.

Article Abstract

Objectives: A prospective clinical trial evaluated the effect of Ga-DOTATOC positron emission tomography-computerized axial tomography (PET-CT) on change in management of patients with lung, pancreatic, and small bowel neuroendocrine tumors. The primary eligibility criterion was a histologically proven tumor with positive somatostatin receptor subtype 2A immunohistochemistry. The primary and secondary end points were change in patient management and safety.

Methods: Referring physicians completed questionnaires pre- and post-Ga-DOTATOC PET-CT, stating current and planned patient management, respectively, with tumor board adjudication of final management decisions. Change in management was categorized as follows: no change; minor change (additional imaging, supportive care); or major change (octreotide/lanreotide therapy, tumor biopsy, surgery, peptide receptor radiotherapy, chemotherapy, biological therapy, liver embolization).

Results: A major change in management was recommended for 54 (47.37%) of 114 subjects and a minor change for 6 (5.26%) of 114 subjects, with no change for 54 (47.37%) of 114 subjects. Grade 1 adverse events were observed in 26 of 114 subjects (nausea, headache, back pain, diarrhea); one grade 2 (petechiae) and one grade 3 (abdominal pain) adverse event were observed. No grade 2 or 3 adverse events were related to study drug and none required intervention.

Conclusions: Imaging with Ga-DOTATOC PET-CT has a significant impact on management of patients with neuroendocrine tumors.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447173PMC
http://dx.doi.org/10.1097/MPA.0000000000001625DOI Listing

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