AI Article Synopsis
- The research explores the origins and fate of quiescent neural stem cells (NSCs) in the adult brain, highlighting that some NSCs are selected during early embryonic development.
- The study employs a GFP-expressing lentivirus to track the lineage and fate of progeny from individual NSCs, revealing that NSCs specify into different lineages before embryonic day 13.5 in mice, producing cells for specific brain regions.
- The findings indicate that most adult NSCs are dormant and infrequently generate new cells, suggesting they may act as a reserve that can be activated later in life.
Article Abstract
The origin and life-long fate of quiescent neural stem cells (NSCs) in the adult mammalian brain remain largely unknown. A few neural precursor cells in the embryonic brain elongate their cell cycle time and subsequently become quiescent postnatally, suggesting the possibility that life-long NSCs are selected at an early embryonic stage. Here, we utilized a GFP-expressing lentivirus to investigate the fate of progeny from individual lentivirus-infected NSCs by identifying the lentiviral integration site. Our data suggest that NSCs become specified to two or more lineages prior to embryonic day 13.5 in mice: one NSC lineage produces cells only for the cortex and another provides neurons to the olfactory bulb. The majority of neurosphere-forming NSCs in the adult brain are relatively dormant and generate very few cells, if any, in the olfactory bulb or cortex, and this NSC population could serve as a reservoir that is occasionally reactivated later in life.
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| http://dx.doi.org/10.1093/cercor/bhaa200 | DOI Listing |
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