Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.
Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in rs243865 in rs11568818 in rs2252070 in and rs28366003 in were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn.
Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for , and non-significant differences in genotypes frequencies among cases and controls were observed.
Conclusions: Analyses of polymorphisms, rs1799750 in , rs243865 in , rs11568818 in , rs2252070 in and rs28366003 in in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.
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| http://dx.doi.org/10.1186/s13053-020-00147-w | DOI Listing |
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