Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Isolated from A Medicinal Plant from Reunion Island.

With the occurrence of antibiotic-resistant strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. , an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against . Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were first isolated from the ethyl acetate extract of leaves. Their structures were elucidated from spectroscopic data. Aspidin VB exhibited strong antibacterial activity against standard and methicillin-resistant strains, with a minimal inhibition concentration (MIC) of 0.25 μg/mL, and no cytotoxicity was observed at 10 M in MRC5 cells. Due to its biological activities, Aspidin VB appears to be a good natural lead in the fight against s.