Radionuclide calibrator responses for Ra in solution and adsorbed on calcium carbonate microparticles.

A suspension of Ra adsorbed onto CaCO microparticles shows promise for α-therapy of intracavitary micro-metastatic diseases. To facilitate accurate activity administrations, geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) have been developed for RaCl solutions and Ra adsorbed onto CaCO microparticles in suspension in ampoules, vials, and syringes. Ampoules and vials give IC responses consistent with each other to <1%. Microparticles attenuation leads to a ≈1% to ≈2.5% reduction in response in the geometries studied.