AI Article Synopsis
- Researchers isolated two new pairs of sesquineolignan enantiomers (1a/1b and 1c/1d) and two pairs of 4',7-epoxy-8,3'-neolignan enantiomers (2a/2b and 3a/3b), along with other compounds from Triadica sebifera.
- The structures and configurations of these compounds were determined through spectroscopic techniques and experimental ECD spectra.
- Compounds 5b, 6a, and 6b exhibited inhibitory effects on NO production in activated microglial BV-2 cells, with respective IC values of 14.3, 23.2, and 33.3
Article Abstract
Two pairs of new sesquineolignan enantiomers (1a/1b and 1c/1d), two pair of new 4',7-epoxy-8,3'-neolignan enantiomers (2a/2b and 3a/3b), and a pair of new 3',7-epoxy-8,4'-oxyneolignan enantiomers (4a/4b), along with two pairs of known 4',7-epoxy-8,3'-neolignan enantiomers (5a/5b and 6a/6b), were obtained from the stems and leaves of Triadica sebifera. The structures of the enantiomers were elucidated by spectroscopic analyses, and their absolute configurations were assigned by the experimental ECD spectra. Among them, compounds 5b, 6a and 6b showed inhibitory activities against NO production in activated microglial BV-2 cells, with IC values of 14.3, 23.2 and 33.3 μM, respectively.
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| http://dx.doi.org/10.1016/j.bioorg.2020.104147 | DOI Listing |
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