AI Article Synopsis
- Electrical disparity in the heart can lead to inefficient performance due to uncoordinated wall motion, causing early wall shortening followed by a rebound stretch during contraction.
- A study of 62 patients with single ventricle indicated that having activation delays in 60-70% of the ventricular wall area was linked to cardiac dysfunction and mechanical discoordination, as well as a prolonged QRS duration.
- Computational simulations revealed that ventricles experiencing activation delays in 70% of their volume are particularly vulnerable to dysfunction, suggesting that the extent of delayed wall activation is crucial in understanding cardiac health.
Article Abstract
Electrical disparity can induce inefficient cardiac performance, representing an uncoordinated wall motion at an earlier activated ventricular wall: an early shortening followed by a systolic rebound stretch. Although regional contractility and distensibility modulate this pathological motion, the effect of a morphological factor has not been emphasized. Our strain analysis in 62 patients with single ventricle revealed that those with an activation delay in 60-70% of ventricular wall area suffered from cardiac dysfunction and mechanical discoordination along with prolonged QRS duration. A computational simulation with a two-compartment ventricular model also suggested that the ventricle with an activation delay in 70% of the total volume was most vulnerable to a large activation delay, accompanied by an uncoordinated motion at an earlier activated wall. Taken together, the ratio of the delayed ventricular wall has a significant impact on the pathophysiology due to an activation delay, potentially highlighting an indicator of cardiac dysfunction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716988 | PMC |
| http://dx.doi.org/10.1186/s12576-020-00765-y | DOI Listing |
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