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Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium.
Toxicol Pathol
December 2024
Wake Forest University, Winston-Salem, North Carolina, USA.
The 2024 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled "Pathology Potpourri," was held in Baltimore, Maryland, at the Society of Toxicologic Pathology's 42nd annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks along with select images that were used by the audience for voting and discussion.
View Article and Find Full Text PDFExisting Forms of Notoginsenoside R in Rats and Their Potential Bioactivities.
J Agric Food Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Article Synopsis
- - Notoginsenoside R (NG-R), a key saponin in a medicinal plant, was analyzed using advanced UHPLC-ESI-Q-TOF-MS/MS techniques to identify its various forms and distribution in rats, resulting in the detection of 105 metabolites, including 89 new ones.
- - The study proposed a new fragmentation pathway for protopanaxatriol (PPT) and revealed novel metabolic reactions for NG-R, such as polyhydroxylation and glucuronidation, with significant metabolite accumulation observed in various organs.
- - Predictive analyses suggested 48 metabolites may have therapeutic effects on three diseases, with follow-up experiments confirming anti-tumor and anti-inflammatory properties in eight specific
Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report.
Perit Dial Int
November 2024
School of Medicine, School of Primary, Community and Social Care, Keele University, Keele, Staffordshire, UK.
Background: Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically important outcome to be reported in all trials. However, there is wide variation in how peritoneal dialysis technique survival is defined, measured and reported, leading to difficulty in comparing or consolidating results.
Methods: We conducted an online international consensus workshop to establish a core outcome measure of technique survival.
Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum.
Kidney Int
December 2024
Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:
Article Synopsis
- The haemolytic uraemic syndromes (HUS) include various conditions, with some linked to complement activation (CaHUS).
- The 2023 International Society of Nephrology HUS Forum featured experts discussing the latest knowledge, uncertainties, and proposed solutions in diagnosing and managing HUS.
- Key areas needing research include naming conventions, complement testing, identifying biomarkers, genetic factors for aHUS, treatment strategies for C5 inhibitors, and improving access to care for patients.
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