An efficient asymmetric aza-Friedel-Crafts reaction of phenols with isatin-derived ketimines is described. The reaction, which was promoted by a Bi(OH)/CPA system, gave a series of chiral 3-amino-2-oxindoles with high yields (up to 99%), excellent enantioselectivities (up to 99%) and moderate to very good regioselectivities (up to 25/1).
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| http://dx.doi.org/10.1039/d0cc04966b | DOI Listing |
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