AI Article Synopsis
- The study examines the relationship between adiponectin and leptin levels in bipolar disorder patients, focusing on their connection to metabolic syndrome and lipid peroxidation in those treated with lithium (Li) and valproic acid (VPA).
- 56 bipolar patients and 31 healthy controls were evaluated using specific criteria to measure metabolic syndrome components and key biomarkers.
- Results indicated that bipolar patients had increased malondialdehyde, BMI, waist circumference, and triglycerides, with decreased HDL-cholesterol and leptin levels, suggesting a need for regular monitoring of metabolic health and lipid levels in these patients.
Article Abstract
Background: The aim of study is to assess a relation between the adiponectin and leptin levels, and metabolic syndrome components and lipid peroxidation treated with Li and VPA in bipolar disorder patients and compared with controls.
Materials And Methods: 56 patients and 31 healthy controls were enrolled. The ATP III criteria were used to determine metabolic syndrome components. Leptin, adiponectin, lipid peroxidation and lipid profiles were measured.
Results: Malondialdehyde in Li patients was higher than VPA patients. BMI, waist circumference (WC), triglyceride, malondialdehyde and adiponectin levels were increased, whereas HDL-cholesterol (VPA treated patients) and leptin were decreased in patients compared with controls. Leptin and adiponectin were correlated with WC, triglyceride and malondialdehyde in both groups. Adiponectin was correlated with HDL-cholesterol in VPA patients.
Conclusion: Patients should be checked metabolic syndrome components, serum leptin and adiponectin level occasionally to prevent possible deficiency or pathologic increase of these parameters.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393417 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2020.e04553 | DOI Listing |
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