AI Article Synopsis
- SARS-CoV-2 relies on ACE2 as a receptor and TMPRSS2 for entering human cells, which are essential for the virus to infect.
- Research was conducted on over 2500 people, revealing significant differences in the genetic factors that affect ACE2 and TMPRSS2 levels among individuals and populations.
- Findings indicate that individuals from African populations may have a genetic tendency for lower levels of these viral entry genes, potentially affecting their susceptibility and severity of COVID-19.
Article Abstract
The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme 2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, and the serine protease TMPRSS2 which allows fusion of the viral and host cell membranes. We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2500 individuals. Our data show significant variability in genetic determinants of ACE2 and TMPRSS2 expression among individuals and between populations, and indicate a genetic predisposition for lower expression levels of both key viral entry genes in African populations. These data suggest that host genetics related to viral entry mechanisms might influence interindividual variability in disease susceptibility and severity of COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484169 | PMC |
| http://dx.doi.org/10.1038/s41435-020-0107-7 | DOI Listing |
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