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Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.
PLoS Med
September 2024
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Background: Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis did suggest clinical benefit, guidelines recommend against its use.
Methods And Findings: Healthy adult participants from the healthcare setting, and later from the community, were enrolled in 26 centres in 11 countries to a double-blind, placebo-controlled, randomised trial of COVID-19 chemoprevention.
Chronic Dermatographic Urticaria Secondary to Systemic Lupus Erythematosus.
Cureus
June 2024
Internal Medicine/Family Medicine, Larkin Community Hospital Palm Springs Campus, Miami, USA.
Article Synopsis
- * A case study of a 26-year-old woman with SLE and chronic dermatographic urticaria showed significant improvement after using hydroxyzine, despite previous unsuccessful treatments.
- * This highlights the need for awareness of rare skin symptoms in SLE and suggests hydroxyzine could be effective for hard-to-treat cases, stressing the importance of further research to develop better treatment approaches.
Background: Clinical guidelines for the treatment of rheumatoid arthritis (RA) recommend reducing the use of glucocorticoids (GCs) due to the high risk of associated complications.
Aim: To determine the frequency of GC cancellations and dose reductions in real clinical practice, while taking into account active RA therapy.
Materials And Methods: The study group consisted of 303 patients with RA reliable according to ACR/EULAR criteria (women 79.
Challenges and Reflections on Pandemic Disinformation: The Case of Hydroxychloroquine and the Implications for Global Public Health.
Value Health Reg Issues
September 2024
State University of Minas Gerais and University Center of Formiga, Ibirité City, Minas Gerais State, Brazil. Electronic address:
This text addresses the implications of misinformation during the COVID-19 pandemic, focusing on the use of hydroxychloroquine (HCQ) and other drugs based on a specific publication. The article titled "Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate," published in 2024 in the journal Biomedicine and Pharmacotherapy, reveals 17 000 deaths associated with the inappropriate use of HCQ in 6 countries, excluding Brazil and India. The dissemination of ineffective drugs, the persistence in recommending HCQ in Brazil, and the lack of an effective response from academia underscore the fragility of public health systems under pressure.
View Article and Find Full Text PDFPrescribing Patterns of Nonrecommended Medications for Children With Acute COVID-19.
Pediatrics
June 2024
Pediatric Hospital Medicine, Department of Pediatrics.
Objective: Repurposed medications for acute coronavirus disease 2019 (COVID-19) continued to be prescribed after results from rigorous studies and national guidelines discouraged use. We aimed to describe prescribing rates of nonrecommended medications for acute COVID-19 in children, associations with demographic factors, and provider type and specialty.
Methods: In this retrospective cohort of children <18 years in a large United States all-payer claims database, we identified prescriptions within 2 weeks of an acute COVID-19 diagnosis.
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