AI Article Synopsis
- The study investigates the controversial link between HLA-C gene variations and psoriatic arthritis (PsA) in European and Middle Eastern populations.
- Researchers analyzed data from 25 studies, finding that specific HLA-C alleles significantly influenced PsA risk: HLA-C*02, *06, and *12 were associated with an increased risk, while HLA-C*04 provided a protective effect.
- The findings suggest that certain HLA-C locus polymorphisms are key factors in determining susceptibility to PsA, highlighting its genetic basis in the evaluated populations.
Article Abstract
Background: Gene-disease association between human leukocyte antigen (HLA)-C locus polymorphism and psoriatic arthritis (PsA) remains controversial.
Objective: Evaluate the relationship between HLA-C locus polymorphism and PsA in populations of European and Middle Eastern descent.
Search Methods: PubMed, PMC, Elsevier and Google Scholar databases from 1980 to January 2020. The search was limited to articles in English.
Selection Criteria: Case-control studies (with unrelated participants) that had allele/genotype data on the association between HLA-C locus polymorphism and PsA susceptibility.
Data Collection And Analysis: Two investigators searched independently in searching the literature. Disagreements were resolved by discussion and consultation with a third researcher. The Q-Genie tool was used to assess the quality of articles.
Results: Twenty-five studies met the inclusion criteria. At the allelic level, three alleles were associated with an increased risk of PsA and five were associated with a reduced risk. At the phenotypic level, four alleles were associated with increased risk of PsA and three were associated with a reduced risk. At both the allelic and phenotypic levels, the results revealed that HLA-C*04 played a protective role in PsA (The pooled odds ratio [OR] is 0.66 for allelic level and 0.63 for phenotypic level), while HLA-C*02, *06 and *12 increased the risk of suffering from PsA (The pooled ORs of C*02, *06 and *12 are 2.21, 2.63 and 1.49 for allelic level, and 1.79, 2.96 and 2.25 for phenotypic level, respectively).
Conclusion: The pooled results showed a significant association between PsA and the HLA-C gene in populations of European and Middle Eastern descent. At both the allelic and phenotypic levels, the HLA-C*02, *06 and *12 may contribute to susceptibility to PsA, while HLA-C*04 may confer a protective role against PsA.
Registration: Not registered.
Conflict Of Interest: None.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410226 | PMC |
| http://dx.doi.org/10.5144/0256-4947.2020.338 | DOI Listing |
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