Background: Differentiating multiple sclerosis (MS) from vascular risk factor (VRF)-small vessel disease (SVD) can be challenging.
Objective And Methods: In order to determine whether or not pontine lesion location is a useful discriminator of MS and VRF-SVD, we classified pontine lesions on brain magnetic resonance imaging (MRI) as central or peripheral in 93 MS cases without VRF, 108 MS patients with VRF and 43 non-MS cases with VRF.
Results: MS without VRF were more likely to have peripheral pons lesions (31.2%, 29/93) than non-MS with VRF (0%, 0/43) (Exp() = 29.8; 95% confidence interval (CI) = (1.98, 448.3); = 0.014) but there were no significant differences regarding central pons lesions between MS without VRF (5.4%, 5/93) and non-MS with VRF patients (16.3%, 7/43) (Exp() = 0.89; 95% CI = (0.2, 3.94); = 0.87). The presence of peripheral pons lesions discriminated between MS and VRF-SVD with 100% (95% CI = (91.8, 100)) specificity. The proportion of peripheral pons lesions in MS with VRF (30.5%, 33/108) was similar to that seen in MS without VRF (31.2%, 29/93, = 0.99). Central lesions occurred in similar frequency in MS with VRF (8.3%, 9/108) and non-MS with VRF (16.3%, 7/43, = 0.15).
Conclusion: Peripheral pons lesion location is a good discriminator of MS from vascular lesions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114427 | PMC |
| http://dx.doi.org/10.1177/1352458520943777 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of cerebellum in controlling eye movements is well established, but its contribution to more complex forms of visual behavior has remained elusive. To study cerebellar activity during visual attention we recorded extracellular activity of dentate nucleus (DN) neurons in two non-human primates (NHPs). NHPs were trained to read the direction indicated by a peripheral visual stimulus while maintaining fixation at the center, and report the direction of the cue by performing a saccadic eye movement into the same direction following a delay.
View Article and Find Full Text PDF[Genetic analysis of a child with Leukoencephalopathy with ataxia caused by a homozygous variant of CLCN2 gene and a literature review].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Department of Neurology, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan 410007, China.
Objective: To explore the clinical manifestations and genetic characteristics of a child with Leukoencephalopathy with ataxia (LKPAT) caused by a CLCN2 gene variant.
Methods: A retrospective analysis was conducted on the clinical data of a child admitted to Hunan Children's Hospital in June 2024 due to "intermittent convulsions for 13 days". Peripheral blood samples were collected from the child and his parents for whole exome sequencing, followed by Sanger sequencing validation and pathogenicity analysis of candidate variants.
Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.
Sci Rep
January 2025
Department of Neurology, Dalian Municipal Central Hospital of Dalian University of Technology, Dalian, 116033, Liaoning, China.
Article Synopsis
- The study examines white matter lesions (WMLs) in migraine patients with right-to-left shunts (RLS), focusing on their location, severity, and impact on brain volume and headaches.
- Researchers analyzed data from 102 migraine sufferers with RLS, including RLS flow and headache impact scores, comparing them with healthy controls.
- Findings indicate WMLs mainly occur in specific brain regions, show no significant correlation with RLS flow, but highlight differences based on headache severity and brain structure between migraines and healthy individuals.
Brain magnetic resonance imaging findings in Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): A case-based review.
Radiol Case Rep
March 2025
Department of Radiology, Medical School, University of Ioannina, Stavros Niarchos Avenue, Ioannina 45500, Greece.
Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare autosomal recessive disorder, manifesting with gastrointestinal dysmotility, cachexia, ptosis and peripheral neuropathy. Diffuse leukoencephalopathy in brain MRI is a hallmark of MNGIE. We report a case of a 21-year-old female with MNGIE, presenting with cachexia and chronic diarrhea.
View Article and Find Full Text PDFNesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice.
Peptides
January 2025
Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao 266000, China. Electronic address:
Article Synopsis
- Obesity is a significant global health concern, and safe treatments are needed.
- The study explored hyperbaric oxygen (HBO) therapy as a potential method to reduce overeating and high energy intake in mice fed a high-fat diet.
- Results showed that HBO treatment decreased food intake and altered brain activity linked to hunger regulation, potentially involving the nesfatin-1 peptide and the melanocortin system.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!