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Experimental models for keratoconus: Insights and challenges.
Exp Eye Res
November 2024
Centre for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre (BHERC), L V Prasad Eye Institute, Hyderabad, India. Electronic address:
Keratoconus, a progressive corneal disorder characterized by the thinning and conical protrusion of the cornea because of collagen degradation, poses significant challenges to both clinicians and researchers. Most successful animal models of keratoconus are based on genetic mutations and knock-outs in mice and rats that hinder normal corneal stromal architecture, thickness, or strength. While mice and rat models are suitable to study the molecular mechanism and physiological changes to the cornea, they are not suitable for experimental research; especially for surgical interventions like: deep anterior lamellar keratoplasty (DALK), stromal lenticule addition keratoplasty, and other advanced therapies.
View Article and Find Full Text PDFOutcomes of Donor Corneas of Different Thicknesses From Endothelial Keratoplasty in Deep Anterior Lamellar Keratoplasty for Keratoconus.
Cornea
July 2024
Department of Ophthalmology, Peking University Third Hospital, Beijing, China; and.
Purpose: To evaluate the outcomes of divided residual donor corneas obtained from endothelial keratoplasty in keratoconus with deep anterior lamellar keratoplasty (DALK).
Methods: In this retrospective, comparative, clinical study, 103 keratoconic eyes that underwent DALK were enrolled; 67 eyes received thin grafts from Descemet stripping automated endothelial keratoplasty, and 36 received thick grafts from Descemet membrane endothelial keratoplasty. Baseline and postoperative central corneal thickness (CCT), inferior corneal thickness, uncorrected distance visual acuity, corrected distance visual acuity, corneal astigmatism, mean keratometry, biomechanical properties, and complication rates were measured.
Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants-A Comprehensive Review.
J Clin Med
April 2024
Department of Ophthalmology, Medical University of Warsaw, Marszałkowska 24/26, 00-576 Warsaw, Poland.
Microbial keratitis in a post-transplant cornea should be considered a distinct entity from microbial keratitis in a non-transplant cornea. Firstly, the use of immunosuppressive treatments and sutures in corneal transplants changes the etiology of keratitis. Secondly, corneal transplant has an impact on corneal biomechanics and structure, which facilitates the spread of infection.
View Article and Find Full Text PDFBiomechanical behavior of deep anterior lamellar keratoplasty: a finite element analysis.
Comput Methods Biomech Biomed Engin
December 2024
National Engineering Research Centre for Human Tissue Reconstruction, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Deep Anterior Lamellar Keratoplasty (DALK) is a surgical procedure used to restore sight and manage corneal diseases by replacing cloudy corneal tissue with allogeneic normal corneal tissue or artificial corneal material. However, the limited availability and mechanical defects of artificial corneal materials pose challenges in DALK. To predicting postoperative mechanical behavior of Deep Anterior Lamellar Keratoplasty (DALK), a three-dimensional finite element model of the postoperative DALK cornea with suture holes was developed.
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