AI Article Synopsis

  • - Esophageal adenocarcinoma (EAC), typically occurring in the distal esophagus, is mainly linked to risk factors like gastroesophageal reflux disease (GERD) and obesity, while squamous cell carcinoma (SCC) affects the proximal esophagus and is associated with tobacco and alcohol use.
  • - EAC shows histological changes from stratified squamous epithelium to non-ciliated columnar cells with goblet cells, contrasting with the histology of SCC.
  • - A case report is presented involving a 59-year-old African American male with dysphagia and weight loss, highlighting a rare instance of EAC affecting the proximal esophagus, which has been largely underrepresented in existing literature.

Article Abstract

Esophageal adenocarcinoma (EAC) is a malignancy classically seen in the distal esophagus. While many risk factors associated with the condition have been reported, the most common among them are gastroesophageal reflux disease (GERD) and obesity. Histological changes range from metaplasia within the esophagus from stratified squamous epithelium to non-ciliated columnar cells with goblet cells. In contrast, squamous cell carcinoma (SCC) is classically found in the proximal portion of the esophagus and its risk factors include tobacco and alcohol use. We present a unique case of a 59-year-old African American male who presented to the ED with dysphagia, weight loss, and multiple episodes of emesis. Notable medical history included tobacco abuse, alcohol abuse, and alcoholic cirrhosis. Currently, there are numerous case reports delineating unique presentations of esophageal cancers; however, there are few case reports that demonstrate EAC affecting the proximal segment of the esophagus.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386092PMC
http://dx.doi.org/10.7759/cureus.8863DOI Listing

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