We report on the self-biasing effect of carrier depletion based silicon microring modulators (MRM) by demonstrating that a silicon MRM can generate open eye diagrams for non-return-to-zero (NRZ) on-off keying (OOK) modulation without an external reverse bias supplied to it. Two modulator configurations are investigated namely single-ended drive in a ground-signal-ground and differential drive in a ground-signal-signal-ground pad configurations. The single-ended modulator is designed with an on photonic integrated circuit (PIC) 50 Ω termination. Open eye diagrams are obtained at 25 Gbit/s and 36 Gbit/s NRZ OOK modulations. We carry-out thorough experimental characterization of the self-biasing of single-ended MRM under various operating conditions of input optical power, carrier wavelength, ring quality factor and extinction ratio as well as modulation speeds, driving voltage swing and pattern length. We demonstrate that the self-biasing is robust and works well in almost all tested conditions. The differential drive MRM is designed with a high impedance without an on-PIC 50 Ω termination. Open eye diagrams are obtained at 30 Gbit/s and 60 Gbit/s NRZ OOK modulations for modulating voltage swing of ∼2.5 V. As demonstrated, the self-biasing works well in both single-ended and differential drive configurations as well as for on-PIC 50 Ω terminated and non-terminated MRMs. The electrical passive parts are all co-designed and fabricated on the same silicon chip as the PIC. The reported self-biasing eliminates the need of having bipolar DC biases supplied to the anode and cathode of the differential drive modulator and allows for simpler driver / modulator interfaces without inductive bias tees.
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Methods Mol Biol
January 2025
Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
StarTrack is a powerful multicolor genetic tool designed to unravel cellular lineages arising from neural progenitor cells (NPCs). This innovative technique, based on retrospective clonal analysis and built upon the PiggyBac system, creates a unique and inheritable "color code" within NPCs. Through the stochastic integration of 12 distinct plasmids encoding six fluorescent proteins, StarTrack enables precise and comprehensive tracking of cellular fates and progenitor potentials.
View Article and Find Full Text PDFArch Womens Ment Health
January 2025
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, 77030, USA.
Purpose: Although many women experience obsessive-compulsive symptoms during the perinatal period, the Yale-Brown Obsessive Compulsive Scale (YBOCS) has not yet been psychometrically evaluated in this population. This study examined the internal consistency, convergent and divergent validity, and factor structure of the YBOCS among pregnant women.
Methods: 256 Women who were 20 to 24 weeks pregnant completed the clinician-administered YBOCS and Mini International Neuropsychiatric Interview (MINI) along with a series of self-report questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS) and Obsessive-Compulsive Inventory-Revised (OCI-R).
J Clin Invest
January 2025
Jeff and Penny Vinik Center for Allergic Disease Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), signals driving human MCT differentiation and this subset's contribution to inflammation remain unexplored. Here, we have identified TGF-β as a key driver of the MCT transcriptome in nasal polyps.
View Article and Find Full Text PDFJ Clin Invest
January 2025
Similarly to acute intestinal helminth infection, several conditions of chronic eosinophilic type 2 inflammation of mucosal surfaces, including asthma and eosinophilic esophagitis, feature robust expansions of intraepithelial mast cells (MCs). Also the hyperplastic mucosa of nasal polyposis in the context of chronic rhinosinusitis, with or without COX1 inhibitor intolerance, contains impressive numbers of intraepithelial MCs. In this issue of the JCI, Derakhshan et al.
View Article and Find Full Text PDFNPJ Syst Biol Appl
January 2025
Department of Mathematics, University of Florida, Gainesville, 32601, FL, USA.
Interconnected feedback loops are prevalent across biological mechanisms, including cell fate transitions enabled by epigenetic mechanisms in carcinomas. However, the operating principles of these networks remain largely unexplored. Here, we identify numerous interconnected feedback loops implicated in cell lineage decisions, which we discover to be the hallmarks of lower- and higher-dimensional state space.
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