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COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? | LitMetric

COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?

Diagnostics (Basel)

Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.

Published: July 2020

AI Article Synopsis

  • - SARS-CoV-2 causes COVID-19, which can lead to severe complications like blood clotting issues (coagulopathy) that are not fully understood; risk for severe cases is higher in males and increases with age.
  • - Researchers found that certain genes related to blood coagulation show differing expressions in males and females, potentially influencing thrombosis risk, but these genes were not affected by SARS-CoV-2 infection.
  • - The study highlights transferrin, a procoagulant that increases with age and is upregulated during SARS-CoV-2 infection in males, suggesting it should be investigated further in understanding COVID-19-related blood clotting.

Article Abstract

SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in females and increases with age. To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term "blood coagulation" in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). However, the expression of none of these genes was regulated in a proteomics dataset of SARS-CoV-2-infected cells and none of the proteins have been identified as a binding partner of SARS-CoV-2 proteins. Hence, they may rather generally predispose individuals to thrombosis without directly contributing to COVID-19-related coagulopathy. In contrast, the expression of the procoagulant transferrin (not associated to the GO term "blood coagulation") was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection. Hence, transferrin warrants further examination in ongoing clinic-pathological investigations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459734PMC
http://dx.doi.org/10.3390/diagnostics10080539DOI Listing

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