Purpose: Glenoid augmentation using free bone blocks for anterior shoulder instability has been proposed as an alternative to or bail-out for the Latarjet procedure. The purpose of this investigation was to systematically review and compare outcomes of patients undergoing glenoid augmentation using free bone block autografts versus allografts.
Methods: A systematic review using PubMed, MEDLINE, Embase, and the Cochrane Library databases was performed in line with the PRISMA statement. Studies reporting outcomes of patients treated with free bone block procedures for anterior shoulder instability with minimum 2-year follow-up were included. Random effects modelling was used to compare patient-reported outcomes, return to sports, recurrent instability, non-instability related complications, and development of arthritis between free bone block autografts and allografts.
Results: Eighteen studies comprising of 623 patients met the inclusion criteria for this investigation. There were six studies reporting on the use of allografts (of these, two used distal tibial, three iliac crest, and one femoral head allograft) in 173 patients and twelve studies utilizing autografts (of these, ten used iliac crest and two used free coracoid autograft) in 450 patients. Mean age was 28.7 ± 4.1 years for the allograft group and 27.8 ± 3.8 years for the autograft group (n.s). Mean follow-up was 98 months in autograft studies and 50.8 months for allograft studies (range 24-444 months, n.s). Overall mean increase in Rowe score was 56.2 with comparable increases between autografts and allografts (n.s). Pooled recurrent instability rates were 3% (95% CI, 1-7%; I = 77%) and did not differ between the groups (n.s). Arthritic progression was evident in 11% of autografts (95% CI, 2-27%; I = 90%) and 1% (95% CI, 0-8%; I = 63%) of allografts (n.s). The overall incidence of non-instability related complications was 5% (95% CI, 2-10%; I = 81%) and was similar between the groups (n.s). Pooled return to sports rate was 88% (95% CI, 76-96%; I = 76%).
Conclusion: Glenoid augmentation using free bone block autograft or allograft in the setting of recurrent anterior shoulder instability with glenoid bone loss is effective and safe. Outcomes and complication incidence using autografts and allografts were comparable. Due to the high degree of heterogeneity in the data and outcomes reported in available studies, which consist primarily of retrospective case series, future prospective trials investigating long-term outcomes using free bone block autograft versus allograft for anterior shoulder instability with glenoid bone loss are warranted.
Level Of Evidence: IV.
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http://dx.doi.org/10.1007/s00167-020-06194-z | DOI Listing |
Int J Mol Sci
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Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas 01001, Peru.
Various types of wounds represent a persistent healthcare burden that demands innovative and effective therapeutic solutions. Innovative approaches have emerged that focus on skin regeneration with minimal side effects. One such method is cell-free therapy that utilizes the secretome of human mesenchymal stem cells (hMSCs) as a promising alternative to traditional cell-based therapies, leveraging a complex mixture of bioactive molecules, including growth factors, cytokines, and extracellular vesicles, to accelerate tissue regeneration.
View Article and Find Full Text PDFPolymers (Basel)
February 2025
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Kraków, Gronostajowa 9, 30-387 Kraków, Poland.
Chitosan and collagen are natural polymers widely used in biomaterials science; however, their inherent low stability and solubility present several challenges to obtain formulations suitable for potential clinical applications. In this study, tannic acid (TA) was employed as a cross-linker to improve the properties of thin films made from chitosan and collagen. In addition, potassium silicate (PS) was added as an inorganic filler, to produce innovative biocomposite films.
View Article and Find Full Text PDFPolymers (Basel)
February 2025
"Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
(1) Background: This review study will delve into the potential of chitosan nanoparticles (NPs) as adaptable carriers for targeted drug delivery in different therapeutic areas. Chitosan is a biopolymer derived from chitin that has attracted interest in drug delivery applications because of its high biocompatibility and biodegradability. (2) Methods: A comprehensive literature review was conducted by following a careful systematized protocol for searching databases like PubMed, Google Scholar and ScienceDirect.
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Given the significant economic and social burden of osteoporosis, there is growing interest in developing an efficient alternative to the traditional dual-energy X-ray absorptiometry (DXA). Radiofrequency Echographic Multi Spectrometry (REMS) is an innovative, non-ionizing imaging technique that recently emerged as a viable tool to diagnose osteoporosis and estimate the fragility fracture risk. Nevertheless, its clinical use is still limited due to its novelty and continuing uncertainty of long-term performance.
View Article and Find Full Text PDFJ Nanobiotechnology
March 2025
Second Clinical Medical College, School of Pharmacy and Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, Shanxi, 030001, People's Republic of China.
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