Context: Thoracic trauma results in multiple rib fractures (MRF), and surgical stabilisation of rib fractures (SSRF) can relieve fracture pain. Epigallocatechin-3-gallate (EGCG) is reported to exhibit beneficial effects in bone-related metabolic and differentiation processes.
Objective: To study the clinical effect of EGCG on regional analgesia for pain relief in MRF patients after SSRF.
Materials And Methods: Ninety-seven MRF patients (61 males, 36 females) who were on epidural catheter analgesia after SSRF were recruited. They were randomly divided into: oral EGCG 100 mg (oral grade) twice daily for 10 days and placebo groups. Pain scores, incentive spirometry (IS) volumes, respiratory rate and oxygen saturation (SpO) were assessed day 10 after SSRF.
Results: Comparing results from the placebo and EGCG group, in the 10-day intervention course, oral EGCG reduced pain score (8 at base line vs. 4 at end of intervention in EGCG group, < 0.05; 4 in EGCG group vs. 6 in placebo group at end of intervention, < 0.05), improved IS volume (713 at base line vs. 1072 at end of intervention in EGCG group, < 0.05; 1072 in EGCG group vs. 953 in placebo group at end of intervention, < 0.05) and respiratory rate (24 at base line vs. 15 at end of intervention in EGCG group, < 0.05; 15 in EGCG group vs. 19 in placebo group at end of intervention, < 0.05). However, no further enhancing effect on SpO was observed in the EGCG group (0.98 in EGCG group vs. 0.98 in placebo group at end of intervention, > 0.05).
Discussion And Conclusions: Although the study is limited by a relatively small sample size and lack of serum factor analysis, the key results and the study design, for the first time, nevertheless pave the way for trials with larger number of patients to understand the effect of EGCG in MRF patients that are undergoing SSRF.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470119 | PMC |
| http://dx.doi.org/10.1080/13880209.2020.1797123 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-Completely Displaced Traumatic Rib Fractures: Potentially Less Crucial for Pulmonary Adverse Outcomes, Regardless of Classification.
Medicina (Kaunas)
January 2025
Department of Trauma Surgery, Jeju Regional Trauma Center, Cheju Halla General Hospital, Jeju 63127, Republic of Korea.
: Two major classification systems exist for rib fracture (RFX) displacement. One system uses a 50% displacement threshold: Grade I (<50%), Grade II (≥50% to <100%), and Grade III (completely dislocated). Another proposes a 10% threshold: Undisplaced (<10%), Offset (≥10% to <100%), and Displaced (completely dislocated).
View Article and Find Full Text PDFImplant irritation and removal rates in operatively treated multiple rib fractures: a 49-month follow-up study.
Eur J Trauma Emerg Surg
January 2025
Department of Orthopedic and Trauma Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Purpose: Little is known about the prevalence, impact and change of the symptoms after implant removal due to irritation in multiple rib fractures. This study aims to explore these aspects to improve treatment decision-making.
Methods: Data was collected from two hospitals in the Netherlands and Switzerland.
Post-discharge complications and follow-up timing after hospitalization for traumatic rib fractures.
Eur J Trauma Emerg Surg
January 2025
Division of General Surgery, Department of Surgery, Stanford University, Stanford, USA.
Purpose: To evaluate frequency and timing of post-discharge complications in patients with traumatic rib fractures undergoing operative or nonoperative management.
Methods: We retrospectively reviewed adult patients with rib fractures admitted to a Level 1 trauma center from 1/2020 to 12/2021. Outcomes included rib-related complications, pneumonia within 1 month, new diagnosis of opioid- or alcohol-use disorder, and all-cause mortality.
Surgical stabilisation of rib fractures in non-ventilated patients: a retrospective propensity-matched analysis using the data from the trauma registry of the German Trauma Society (TraumaRegister DGU).
Eur J Trauma Emerg Surg
January 2025
Department for Trauma-, Hand- and Reconstructive Surgery, University Hospital Münster, Münster, Germany.
Purpose: Severe thorax trauma including multiple rib fractures and flail chest deformity are leading causes of death in trauma patients. Increasing evidence supports the use of surgical stabilisation of rib fractures (SSRF) in these patients. However, there is currently a paucity of evidence for its use in non-ventilator-dependent patients.
View Article and Find Full Text PDFAI-assisted radiologists vs. standard double reading for rib fracture detection on CT images: A real-world clinical study.
PLoS One
January 2025
Department of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
To evaluate the diagnostic accuracy of artificial intelligence (AI) assisted radiologists and standard double-reading in real-world clinical settings for rib fractures (RFs) detection on CT images. This study included 243 consecutive chest trauma patients (mean age, 58.1 years; female, 166) with rib CT scans.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!