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Squalene: More than a Step toward Sterols. | LitMetric

Squalene: More than a Step toward Sterols.

Antioxidants (Basel)

Department of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.

Published: August 2020

AI Article Synopsis

Article Abstract

Squalene (SQ) is a natural triterpene widely distributed in nature. It is a metabolic intermediate of the sterol biosynthetic pathway and represents a possible target in different metabolic and oxidative stress-related disorders. Growing interest has been focused on SQ's antioxidant properties, derived from its chemical structure. Strong evidence provided by ex vivo models underline its scavenging activity towards free radicals, whereas only a few studies have highlighted its effect in cellular models of oxidative stress. Given the role of unbalanced free radicals in both the onset and progression of several cardiovascular diseases, an in depth evaluation of SQ's contribution to antioxidant defense mechanisms could represent a strategic approach in dealing with these pathological conditions. At present experimental results overall show a double-edged sword role of squalene in cardiovascular diseases and its function has to be better elucidated in order to establish intervention lines focused on its features. This review aims to summarize current knowledge about endogenous and exogenous sources of SQ and to point out the controversial role of SQ in cardiovascular physiology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464659PMC
http://dx.doi.org/10.3390/antiox9080688DOI Listing

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