AI Article Synopsis
- SNARE proteins are crucial for various cellular processes like vesicle trafficking and synaptic transmission, with SEC22B being a key player in membrane fusion between the endoplasmic reticulum and Golgi apparatus.
- SEC22B is linked to multiple human diseases, including various cancers, where mutations have been observed.
- The review aims to highlight SEC22B's specific functions and its relevance in diseases, paving the way for future research on its underlying mechanisms and potential treatment strategies.
Article Abstract
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are a large protein complex that is involved in the membrane fusion in vesicle trafficking, cell growth, cytokinesis, membrane repair, and synaptic transmission. As one of the SNARE proteins, SEC22B functions in membrane fusion of vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus, antigen cross-presentation, secretory autophagy, and other biological processes. However, apart from not being SNARE proteins, there is little knowledge known about its two homologs (SEC22A and SEC22C). SEC22B alterations have been reported in many human diseases, especially, many mutations of SEC22B in human cancers have been detected. In this review, we will introduce the specific functions of SEC22B, and summarize the researches about SEC22B in human cancers and other diseases. These findings have laid the foundation for further studies to clarify the exact mechanism of SEC22B in the pathological process and to seek new therapeutic targets and better treatment strategies.
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| http://dx.doi.org/10.1002/cm.21628 | DOI Listing |
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