A striking feature of many natural magnetic fields generated by dynamo action is the occurrence of polarity reversals. Paleomagnetic measurements revealed that the Earth's magnetic field has been characterised by few hundred stochastic polarity switches during its history. The rate of reversals changes in time, maybe obeying some underlying regular pattern. While chaotic dynamical systems can describe the short-term behaviour of the switches of the Earth's magnetic polarity, modelling the long-term variations of the reversal rate is somewhat problematic, as they occur on timescales of tens to hundreds of millions of years, of the order of mantle convection timescales. By investigating data of geomagnetic reversal rates, we find the presence of cycles with variable frequency and show that the transition towards periods where reversals do not occur for tens of million years (superchrons) can be described by a second-order phase transition that we interpret to be driven by variations of the heat flux at the core-mantle boundary (CMB). The model allows us to extract from the reversal sequence quantitative information on the susceptibility of the reversal rate caused by changes in the CMB heat flux amplitude, thus providing direct information on the deep inner layers of the Earth.
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http://dx.doi.org/10.1038/s41598-020-69916-w | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, 613 West of Huangpu Avenue, Guangzhou, 510630, China.
E3 ubiquitin ligases have the potential to modulate key oncogenic pathways. RING finger protein 123 (RNF123), as an E3 ubiquitin ligase, has been functioned as a tumor suppressor. This study was designed to explore the role of RNF123 in breast cancer.
View Article and Find Full Text PDFPhysiol Rep
December 2024
Department of Cardiology, St George's University Hospitals NHS Foundation Trust, London, UK.
The effects of triathlon exercise on cardiac function are well documented. While Olympic triathlon (swim-bike-run) remains the standard format, increasing concerns about water quality in natural waterways present ongoing challenges for open-water swimming events, highlighting the potential need to consider alternative formats such as duathlon (run-bike-run) in some circumstances. An additional run may increase the overall metabolic and cardiovascular demand compared with the swim in triathlon, leading to reduced future performance.
View Article and Find Full Text PDFObjectives: To understand the competitive position of the UK in comparison to Europe and the USA for haematological cancer clinical research.
Design: Using commercially available databases, clinical trial numbers, their effectiveness and publication outputs were evaluated in two analyses: a macrodevelopment and a research activity and performance analysis.
Data Sources: The following databases were used for this analysis: Organisation for Economic Co-operation and Development, Thomson Reuters Incidence and Prevalence, the Cortellis Clinical Trial Intelligence, the Clarivate Cortellis Innography Patent Intelligence, Thomson-Reuters Cortellis Regulatory Intelligence, Thomson Reuters Web of Science and data from the Centre for Medicine Research (CMR).
Brain Res
December 2024
Department of Urology Surgery, People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, China.
Background: Postoperative cognitive dysfunction (POCD) is a significant surgery-related complication marked by cognitive decline. Studies indicated that neuroinflammation, ferroptosis, and mitochondrial fatty acid metabolism might play parts in POCD, and might be mediated by Carnitine palmitoyl transferase 1a (CPT1A), but requires further investigations. Therefore, this study aims to investigate the mechanism of mitochondrial fatty acid oxidase CPT1A on mitochondrial function, ferroptosis, and inflammation in POCD pathogenesis.
View Article and Find Full Text PDFPlant Dis
December 2024
Honghe University, College of Biological and Agricultural Sciences, Mengzi, Yunnan, China;
The Asteraceae family plant Erigeron breviscapus (Vant.) Hand.-Mazz.
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