In the present research, we prepared new glycodendrimer containing β-cyclodextrin (β-CD) in three steps. At first, graphene quantum dots (GQDs) synthesized through pyrolysis of the citric acid (CA). Then the polyamidoamine (PAMAM) dendrimer was grown from the surface of the modified GQDs (GQDs-PAMAM). Finally, the prepared GQDs-PAMAM was functionalized with β-CD to obtain the glycodendrimer (GQDs-PAMAM-β-CD). The synthesized glycodendrimer characterized using several techniques. The phenol-sulfuric acid test obtained the amount of the β-CD about 30.37 %. 61.2 % of doxorubicin (DOX) was loaded in the prepared glycodendrimer. DOX@GQDs-PAMAM-β-CD displayed the pH-sensitive drug release profile, which fitted the Higuchi kinetic model. The biological test outcomes showed that the GQDs-PAMAM-β-CD is a safe carrier with good capability in penetration to the cancer cells. Moreover, DOX@GQDs-PAMAM-β-CD exhibited more efficiency in the killing of the cancer cells compared to neat DOX. Obtained results suggested that prepared glycodendrimer could be a potential nanosystem for breast cancer treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2020.116658 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring Rigid and Flexible Scaffolds to Develop Potent Glucuronic Acid Glycodendrimers for Dengue Virus Inhibition.
Bioconjug Chem
January 2024
Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plz. Ramón y Cajal s/n, Madrid, C.P. 28040, España.
Multivalent glycodendrimers are valuable tools for studying carbohydrate-protein interactions, and their scaffolds represent important components to increase specificity and affinity. Previous work by our group described the preparation of a tetravalent glucuronic acid rigid dendron that binds with good affinity to the dengue virus envelope protein ( = 22 μM). Herein, the chemical synthesis and binding analysis of three new sets of rigid, semirigid, and flexible glucuronic acid-based dendrimers bearing different levels of multivalency and their interactions with the dengue virus envelope protein are described.
View Article and Find Full Text PDFAdvanced high-affinity glycoconjugate ligands of galectins.
Bioorg Chem
February 2023
Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic; Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, CZ-272 01 Kladno, Czech Republic. Electronic address:
Galectins are proteins of the family of human lectins. By binding terminal galactose units of cell surface glycans, they moderate biological and pathological processes such as cell signaling, cell adhesion, apoptosis, fibrosis, carcinogenesis, and metabolic disorders. The binding of monovalent glycans to galectins is usually relatively weak.
View Article and Find Full Text PDFpH-responsive glycodendrimer as a new active targeting agent for doxorubicin delivery.
Int J Biol Macromol
November 2022
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
The present study synthesized a new kind of pH-responsive active targeting glycodendrimer (ATGD) for doxorubicin delivery to cancerous cells. First, the glycodendrimer was synthesized based on the cultivation of chitosan dendrons on amine-functionalized, silica-grafted cellulose nanocrystals. Afterward, glycodendrimer was conjugated with folic acid to provide a folate receptor-targeting agent.
View Article and Find Full Text PDFBiocatalyzed Synthesis of Glycostructures with Anti-infective Activity.
Acc Chem Res
September 2022
Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Molecules containing carbohydrate moieties play essential roles in fighting a variety of bacterial and viral infections. Consequently, the design of new carbohydrate-containing drugs or vaccines has attracted great attention in recent years as means to target several infectious diseases.Conventional methods to produce these compounds face numerous challenges because their current production technology is based on chemical synthesis, which often requires several steps and uses environmentally unfriendly reactants, contaminant solvents, and inefficient protocols.
View Article and Find Full Text PDFDendritic maleimide-thiol adducts carrying pendant glycosides as high-affinity ligands.
Bioorg Chem
November 2022
Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan; Medical Innovation Research Unit (MiU), Advanced Institute of Innovative Technology (AIIT), Saitama University, Sakura, Saitama 338-8570, Japan; Area for Health Science, Strategic Research Center, Saitama University, Sakura, Saitama 338-8570, Japan. Electronic address:
We synthesized N-acetylglucosamine-terminated hexavalent carbosilane dendrimers and investigated their binding to wheat germ agglutinin (WGA). The glycodendrimers were prepared by the conjugation of 3-mercaptopropyl, 4-mercaptobutyl, or 5‑mercaptopentyl glycosides to maleimide-terminated hexavalent carbosilane dendrimers. Titration of WGA with the glycodendrimers yielded quenching of tryptophan fluorescence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!