Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K/Akt signaling pathways.

Food Chem

Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China; International Research Centre for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Published: January 2021

Zhenjiang aromatic vinegar is a famous traditional fermented cooking ingredient in China, with multiple nutritional and medicinal applications. Zhenjiang aromatic vinegar extract (100-400 μg/mL) is rich in polyphenols increased the glucose uptake and glucose consumption in high glucose-induced insulin resistant HepG2 (IR-HepG2) cells. Zhenjiang aromatic vinegar extract enhanced glycogen synthesis and attenuated gluconeogenesis by regulating key enzymes in IR-HepG2 cells. In addition, Zhenjiang aromatic vinegar extract ameliorated high glucose-induced IR by inhibiting phosphorylated insulin receptor substrate-1 (IRS-1) expression and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Moreover, Zhenjiang aromatic vinegar extract reduced reactive oxygen species generation and phosphorylated c-Jun NH terminal kinase (JNK) expression in IR-HepG2 cells. The attenuation of the high glucose is owned to the PI3K/Akt pathway activation, glycogen synthesis induction and gluconeogenesis suppression in IR-HepG2 cells.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127513DOI Listing

Publication Analysis

Top Keywords

zhenjiang aromatic
24
aromatic vinegar
24
ir-hepg2 cells
20
vinegar extract
16
high glucose-induced
12
glucose-induced insulin
8
cells zhenjiang
8
glycogen synthesis
8
zhenjiang
6
aromatic
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!