Intertidal sediment samples from Shilaoren Bay, Qingdao, China, were collected to determine the concentrations and compositions of 16 polycyclic aromatic hydrocarbons (PAHs). The sources of PAHs were analyzed, and risk assessment was performed. Results show that the pollution level of PAHs in the investigated area was low. The majority of PAHs are four-ring PAHs. The PAHs in this region were mainly derived from combustion sources, including the incomplete combustion of petroleum, coal, and biomass, such as vegetation, which were affected to some extent by petroleum sources. The highest concentration of PAHs in all sampling sites was lower than that of effects range low, and the mean effects range median quotient was low. Therefore, the PAHs in the study area did not have toxic and side effects on the ecological environment, and ecological risk was low.
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http://dx.doi.org/10.1016/j.marpolbul.2020.111499 | DOI Listing |
Palliat Support Care
March 2025
Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.
Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.
Front Immunol
March 2025
State Key Laboratory of Experimental Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Introduction: Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.
View Article and Find Full Text PDFAm J Case Rep
March 2025
Department of Pharmacy, Yokohama City Minato Red Cross Hospital, Yokohama, Kanagawa, Japan.
BACKGROUND Dextromethorphan is a widely used over-the-counter antitussive medication. Generally safe within the recommended dosages, its misuse can lead to severe adverse effects, particularly in large amounts. However, comprehensive descriptions of severe overdose cases - including pharmacokinetic data of dextromethorphan and its active metabolite (dextrorphan) - are scarce.
View Article and Find Full Text PDFNutrients
February 2025
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
: Post-menopausal women are at an increased risk of developing cardiovascular disease. Menaquinone-7 (MK-7) is a fat-soluble vitamin involved in coagulation and maintaining vascular health. The aim of the post hoc analysis of this one-year study is to investigate the effects of MK-7 supplementation on the vascular parameters in pre-, peri-, and post-menopausal women.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Department of Chemistry & Biochemistry, George Mason University, Fairfax, VA 22030, USA.
Feedstock plants for biofuel production can be cultivated on polluted sites that are unsuitable for edible crop production. This approach combines environmental restoration and renewable energy production, therefore enhancing the economic viability of plant-derived biofuels. Previous studies have indicated that exposure to environmental pollutants may elevate lignin levels in exposed plants, potentially impacting the biomass digestibility and the efficiency of bioethanol conversion.
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