AI Article Synopsis
- Neuroblastoma survivors experience early signs of weakened immune response, particularly in their CD8 T cells, shortly after therapy.
- They also show elevated levels of TNF-α in their plasma, indicating inflammation.
- Over time, some signs of immune recovery are noted, but it's unclear if this recovery is permanent or temporary, especially given that late side effects are common in childhood cancer survivors.
Article Abstract
Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8 T cell compartment and elevated plasma TNF-α but in later follow-up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754117 | PMC |
| http://dx.doi.org/10.1002/eji.202048541 | DOI Listing |
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