Long-term combination treatment with lenalidomide and low-dose dexamethasone is important to achieve a curative effect in patients with multiple myeloma (MM). In this study, the plasma concentration of lenalidomide was measured at 3 h after oral administration, when the drug is in the elimination phase and can be easily measured in outpatients, to identify factors that may lead to the discontinuation of this combination therapy. Patients were assigned to continuation or discontinuation of therapy groups, and the baseline characteristics of patients, lenalidomide concentration, and concentration/dose (C/D) ratios reflecting oral clearance were compared between the two groups. The efficacy and severity of adverse events were also compared. The results showed that patients who discontinued or modified treatment had low plasma concentrations of lenalidomide and C/D ratios, indicating high oral clearance of lenalidomide. The estimated creatinine clearance rate was negatively correlated with the C/D ratio. The plasma concentrations of lenalidomide were independent from kidney function and differed significantly among patients. Taken together, the results indicate that low plasma concentrations of lenalidomide and low C/D ratios may lead to discontinuation of combination therapy in patients with MM. This suggests that early measurement of lenalidomide plasma continuation would help to prevent discontinuation of therapy or a delay in modifying the dose of lenalidomide.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1248/bpb.b20-00337 | DOI Listing |
Cells Dev
December 2024
Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA. Electronic address:
The aorta exhibits tremendous changes in geometry, composition, and mechanical properties during postnatal development. These changes are necessarily driven by transcriptional changes, both genetically programmed and mechano-responsive, but there has not been a careful comparison of time-course changes in the transcriptional profile and biomechanical phenotype. Here, we show that the greatest period of differential gene expression in the normal postnatal mouse aorta occurs prior to weaning at three weeks of age though with important evolution of many transcripts thereafter.
View Article and Find Full Text PDFCells Dev
March 2024
North Carolina State University, Raleigh, NC, USA. Electronic address:
The biomechanics of embryonic notochords are studied using an elastic membrane model. An initial study varying internal pressure and stiffness ratio determines tension and geometric ratios as a function of internal pressure, membrane stiffness ratio, and cell packing pattern. A subsequent three-point bending study determines flexural rigidity as a function of internal pressure, configuration, and orientation.
View Article and Find Full Text PDFCells Dev
March 2023
North Carolina State University, Raleigh, NC, USA. Electronic address:
The physical and geometric aspects of notochords are investigated using a model of finite-length notochords, with interior vacuolated cells arranged in two common packing configurations, and sheath modeled as homogeneous and thin. The key ratios governing packing patterns and eccentricity are number of cells per unit length λ and cell tension ratio Γ. By analyzing simulations that vary Γ and total number of cells N, we find that eccentricity, λ, and internal pressure approach consistent asymptotic values away from the tapering ends, as N increases.
View Article and Find Full Text PDFCells Dev
June 2022
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA. Electronic address:
Cells Dev
March 2022
North Carolina State University, Raleigh, NC, USA. Electronic address:
This paper develops a theoretical basis for the observed relationship between cell arrangements in notochords and analog physical models, and the eccentricity of their cross sections. Three models are developed and analyzed, of the mechanics of cell packing in sheaths. The key ratios governing the packing patterns and eccentricity are cells per unit length λ, tension ratio Γ, and eccentricity e.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!