AI Article Synopsis
- Malaria is a major global health issue, particularly in South-East Asia where traditional remedies using medicinal plants like Piper betle are common.
- In this study, the compound allylpyrocatechol from Piper betle was confirmed to have anti-malarial effects when tested in living organisms using both injection and oral methods.
- Researchers also synthesized related compounds to investigate which specific chemical structures contribute to the anti-malarial effectiveness of allylpyrocatechol.
Article Abstract
Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection "hot-spots," medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure-activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.
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| http://dx.doi.org/10.1248/cpb.c20-00294 | DOI Listing |
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