A 70-year-old man presented with dizziness and unsteadiness when standing and was hospitalized in another hospital. Magnetic resonance imaging (MRI) of the brain on Day 1 showed no abnormalities. The patient developed respiratory failure on Day 1and flaccid tetraplegia on Day 3, and was transferred to our hospital. Progressive upper and lower limb weakness and bulbar symptoms suggested Guillain-Barré syndrome or its variant. Diffusion-weighted MRI on Day 6 disclosed high signal intensities in the bilateral medial portion of the medulla, and the patient was diagnosed with bilateral medial medulla infarction. Bilateral medial medulla infarction should be considered when a patient shows progressive tetraplegia, and bulbar palsy and follow-up MRI is important to confirm the diagnosis. (Received January 23, 2020; Accepted April 21, 2020; Published August 1, 2020).
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http://dx.doi.org/10.11477/mf.1416201617 | DOI Listing |
Nat Commun
December 2024
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Growth differentiation factor 15, GDF15, and glucagon-like peptide-1 (GLP-1) analogues act through brainstem neurons that co-localise their receptors, GDNF-family receptor α-like (GFRAL) and GLP1R, to reduce food intake and body weight. However, their use as clinical treatments is partially hampered since both can also induce sickness-like behaviours, including aversion, that are mediated through a well-characterised pathway via the exterolateral parabrachial nucleus. Here, in mice, we describe a separate pathway downstream of GFRAL/GLP1R neurons that involves a distinct population of brain-derived neurotrophic factor (BDNF) cells in the medial nucleus of the tractus solitarius.
View Article and Find Full Text PDFJ Neurotrauma
December 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, we use a swine model of high-energy BHBT to characterize key neuropathologies and their association with acute respiratory decompensation. Animals with either stable or critical vital signs were euthanized within 4 h after injury for neuropathological assessment, with emphasis on axonal and vascular pathologies in the brainstem.
View Article and Find Full Text PDFJ Assoc Physicians India
December 2024
Neurologist, Department of Neurology, Brain and Spine Centre, Vaikom, Kerala, India.
A 52-year-old man with a 5-year history of diabetes mellitus and chronic renal disease presented with sudden onset left upper limb weakness and numbness at 5 pm, which progressed to quadriplegia by the next day at 2:30 am. He had dysarthria at admission. There were no sensory symptoms in the lower limbs.
View Article and Find Full Text PDFRadiology
December 2024
From the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Cureus
September 2024
Internal Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Bilateral medullary syndrome (BMS) is an extremely rare and devastating neurological disorder resulting from ischemia or infarction of the medulla oblongata. This case report presents two unique instances of BMS, both leading to fatal outcomes. Case 1 describes a 70-year-old male with a history of systemic hypertension who presented with limb weakness, slurred speech, and dysphagia.
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