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http://dx.doi.org/10.1016/j.cxom.2020.06.002 | DOI Listing |
Genome Med
December 2024
European Reference Network for Rare Multisystemic Vascular Disease (VASCERN), HTAD and MSA Rare Disease, Working Group, Paris, France.
Background: In 2015, the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) developed standardized variant curation guidelines for Mendelian disorders. Although these guidelines have been widely adopted, they are not gene- or disease-specific. To mitigate classification discrepancies, the Clinical Genome Resource FBN1 variant curation expert panel (VCEP) was established in 2018 to develop adaptations to the ACMG/AMP criteria for FBN1 in association with Marfan syndrome.
View Article and Find Full Text PDFBMJ Paediatr Open
December 2024
Jinan University, Guangzhou, Guangdong, China
Background: Death rates in the intensive care unit (ICU) and paediatric ICU (PICU) are approximately 10.8% and 9.13%, respectively.
View Article and Find Full Text PDFAm J Crit Care
January 2025
Shih-Hua Lin is a professor, Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei.
Background: Hyperkalemia can be detected by point-of-care (POC) blood testing and by artificial intelligence- enabled electrocardiography (ECG). These 2 methods of detecting hyperkalemia have not been compared.
Objective: To determine the accuracy of POC and ECG potassium measurements for hyperkalemia detection in patients with critical illness.
Soc Sci Med
December 2024
Nursing Administration, Mayo Clinic, Rochester, MN, USA.
Efforts to improve diversity, equity, and inclusion (DEI) in healthcare have increased, targeting healthcare worker biases with the goal of increasing inclusion of employees from racial and ethnic minoritized groups and improving care for patients from these groups. Virtual reality (VR) remains an underutilized mechanism for effecting behavior and attitude change. VR educational interventions work through two primary pathways, behavior rehearsal and embodiment.
View Article and Find Full Text PDFJ Diabetes Complications
December 2024
Sinai Health System, Division of General Internal Medicine, Toronto, Ontario, Canada; Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario. Electronic address:
Aims: To identify factors associated with use of novel diabetes medications among patients hospitalized under general internal medicine.
Methods: We conducted a cohort study of patients with type 2 diabetes mellitus (T2DM) hospitalized in Ontario, Canada between 2015 and 2020. We evaluated the patient- and physician-level factors associated with sodium-glucose cotransporter 2 inhibitor (SGLT2) and glucagon-like peptide 1 receptor agonist (GLP1R) use using a multivariable logistic regression model.
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