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Comparison of neuraminidase inhibiting antibody responses elicited by egg- and cell-derived influenza vaccines.
Vaccine
January 2025
Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Electronic address:
Unlabelled: Neuraminidase (NA)-specific antibodies contribute to immunity against influenza. While studies have demonstrated increased NA inhibiting (NAI) antibody titers after vaccination with egg-derived inactivated influenza vaccines (eIIV), the response to cell culture-derived (c) IIV has not been reported.
Methods: An immunogenicity sub-study was performed within a clinical trial comparing the effectiveness of egg, cell, and recombinant hemagglutinin (HA)-derived influenza vaccines during the 2018-2019 and 2019-2020 influenza seasons.
Establishing bio-logging data collections as dynamic archives of animal life on Earth.
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Centre for Biological Diversity, School of Biology, University of St Andrews, St Andrews, UK.
Rapid growth in bio-logging-the use of animal-borne electronic tags to document the movements, behaviour, physiology and environments of wildlife-offers opportunities to mitigate biodiversity threats and expand digital natural history archives. Here we present a vision to achieve such benefits by accounting for the heterogeneity inherent to bio-logging data and the concerns of those who collect and use them. First, we can enable data integration through standard vocabularies, transfer protocols and aggregation protocols, and drive their wide adoption.
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Travel restrictions during the novel coronavirus, SARS-CoV-2 (COVID-19) public health emergency affected the U.S. Food and Drug Administration's (FDA) ability to conduct on-site bioavailability/bioequivalence (BA/BE) and Good Laboratory Practice (GLP) nonclinical inspections.
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NOAA/Pacific Marine Environmental Laboratory, Seattle, Washington DC 20005, USA.
El Niño-Southern Oscillation (ENSO) exhibits a strong asymmetry between warm El Niño and cold La Niña in amplitude and temporal evolution. An El Niño often leads to a heat discharge in the equatorial Pacific conducive to its rapid termination and transition to a La Niña, whereas a La Niña persists and recharges the equatorial Pacific for consecutive years preconditioning development of a subsequent El Niño, as occurred in 2020-2023. Whether the multiyear-long heat recharge increases the likelihood of a transition to a strong El Niño remains unknown.
View Article and Find Full Text PDFCanadian forests are more conducive to high-severity fires in recent decades.
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Department of Forest Resources Management, Faculty of Forestry, The University of British Columbia, Vancouver, BC, Canada.
Canada has experienced more-intense and longer fire seasons with more-frequent uncontrollable wildfires over the past decades. However, the effect of these changes remains unknown. This study identifies driving forces of burn severity and estimates its spatiotemporal variations in Canadian forests.
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