AI Article Synopsis

  • Autism is a developmental disorder characterized by repetitive behaviors, social challenges, and language issues, and this study examines autistic individuals using DSM IV-TR criteria.
  • Significant differences were found between autistic subjects and controls in terms of neurotransmitter levels, oxidative stress, and certain biochemical markers, with controls showing notable increases in antioxidant levels and enzyme concentrations.
  • The findings highlight the need for a comprehensive approach to autism research that integrates biochemical assessments and neurotransmitter analysis.

Article Abstract

Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two groups of autistic subjects (group I < 12 years; group II ≥ 12 years). Antioxidants show a variation of 10% increase in controls compared to autistic age < 12 years. The concentration of pyruvate kinase and hexokinase is elevated in controls approximately 60% and 45%, respectively, with the significance of 95 and 99%. Autistic subjects showed marked variation in levels of neurotransmitters, oxidative stress and its related ions. Cumulative assessment of parameters related to biochemical markers and neurotransmitters paves the way for autism-based research, although these observations draw interest in an integrated approach for autism.

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http://dx.doi.org/10.1007/s11010-020-03851-2DOI Listing

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